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Clonal selection and learning in the antibody system

Nature volume 381, pages 751–758 (1996)Cite this article

Abstract

Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of ordered gene rearrangements which must be successfully performed if the cell is to survive. A second selection process occurs during immune responses in which a new antibody repertoire is generated through somatic hypermutation. Here only mutants binding antigen with high affinity survive to become memory cells. Cells expressing autoreactive receptors are counter-selected at both stages. This stringent positive and negative selection allows the generation and diversification of cells while rigorously controlling their specificity.

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  1. Institute of Genetics, University of Cologne, Weyertal 121, D-50931, Cologne, Germany

    Klaus Rajewsky

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Rajewsky, K. Clonal selection and learning in the antibody system. Nature 381, 751–758 (1996). https://doi.org/10.1038/381751a0

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