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Acknowledgements
This work was supported by grants from the NIH (to P.N.) and the Yale Diabetes Endocrinology Research Center (to C.W.-S.). We thank M. Solimena, P. De Camilli and C. M. Carr for critical reading of the manuscript; E. O’Neill and M. Travers for technical assistance; S. Wolin for the anti-Lhp1 antibody and discussions; M. Snyder for providing yeast strains containing 3× haemagglutinin-tagged Chs5; G.Waters for the haemagglutinin–OCH1 plasmid; and J. Valentijn for help with computer programs. Microscopy studies were partially carried out with support of the Yale Diabetes Endocrinology Research Center (DERC) Cell Biology Core.
Correspondence and requests for materials should be addressed to P.N.
Supplementary information is available on Nature Cell Biology’s World-Wide Web site (http://cellbio.nature.com) or as paper copy from the London editorial office of Nature Cell Biology.
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Figure S1
The pik1-101 mutant allele blocks endocytosis at the endosome. (PDF 714 kb)
Figure S2
Characterization of the anti-Pik1p antibody. (PDF 100 kb)
Figure S3
The nuclear proteins Pik1p and Lhp1p translocate rapidly from the nucleus to the cytoplasm upon a block in secretion. (PDF 1648 kb)
Table S1
Viability of pik1-101 double mutants. (PDF 44 kb)
Table S2
Relevant yeast strains. (PDF 3 kb)
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Walch-Solimena, C., Novick, P. The yeast phosphatidylinositol-4-OH kinase Pik1 regulates secretion at the Golgi. Nat Cell Biol 1, 523–525 (1999). https://doi.org/10.1038/70319
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DOI: https://doi.org/10.1038/70319
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