Multiple mechanisms regulate adipose mass and body weight. In addition to factors controlling appetite and energy expenditure, mechanisms controlling adipocyte number, triglyceride synthesis and triglyceride breakdown have important functions. But recent studies challenge our concepts concerning each of these.
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References
Smith, S.J. et al. Nature Genet. 25, 87– 90 (2000).
Flier, J.S. & Maratos-Flier, E. Cell 92, 437–440 (1998).
Friedman, J.M. & Halaas, J.L. Nature 395, 763–770 (1998).
Hagan, M.M. et al. J. Neurosci. 19, 2362– 2367 (1999).
Zhang, Y. et al. Nature 372, 425–432 (1994).
Montague, C.T. et al. Nature 387, 903–908 (1997).
Lee, G.H. et al. Nature 379, 632–635 (1996).
Marsh, D.J. et al. Nature Genet. 21, 119– 122 (1999).
Shimada, M., Tritos, N.A., Lowell, B.B., Flier, J.S. & Maratos-Flier, E. Nature 396, 670–674 (1998).
Ricquier, D. & Bouillaud, F. Biochem. J. 345, 161–179 (2000).
Lowell, B.B. et al. Nature 366, 740–742 (1993).
Enerback, S. et al. Nature 387, 90–93 (1997).
Argyropoulos, G. et al. J. Clin. Invest. 102, 1345– 1351 (1998).
Wu, Z., Puigserver, P. & Spiegelman, B.M. Curr. Opin. Cell. Biol. 11, 689–694 (1999).
Shimomura, I. et al. Genes Dev. 12, 3182– 3194 (1998).
Gavrilova, O., Marcus-Samuels, B., Leon, L.R., Vinson, C. & Reitman, M.L. Nature 403, 850–851 (2000).
Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W. & Kahn, C.R. N. Engl. J. Med. 339, 953–959 (1998).
Beamer, B.A. et al. Diabetes 47, 1806– 1808 (1998).
Osuga, J. et al. Proc. Natl Acad. Sci. USA. 97, 787– 792 (2000).
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Kahn, C. Triglycerides and toggling the tummy. Nat Genet 25, 6–7 (2000). https://doi.org/10.1038/75610
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DOI: https://doi.org/10.1038/75610
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