Abstract
The secretion of CEA into the blood of athymic mice was studied with 4 sublines of human colonic adenocarcinoma cell lines, HT 29 and SLu. Growth curves based on tumour volume (caliper measurements) or tumour mass (weight) correlated with a concomitant increase of serum CEA during the logarithmic growth phase, but showed a marked dissociation when the growth rate slowed down. In the logarithmic growth phase doubling times between 2 and 6 days were calculated and about 6-7 doubling times passed until the shift in the growth rate was observed, independently of the sublines transplanted. Constant increases of CEA between 0.03 and 0.45 microgram/l serum per mm3 increase of tumour volume, depending on the sublines, were recorded during the logarithmic growth phase. Sublines releasing high amounts of CEA in vitro (cell culture) retained this characteristic in vivo. Correlation between tumour volume and tumour mass or serum CEA showed correlation coefficients of 0.820-0.977 during the logarithmic growth phase.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Staab, H., Anderer, F. Growth of human colonic adenocarcinoma and development of serum CEA in athymic mice. I: strict correlation of tumour size and mass with serum CEA concentration during logarithmic growth. Br J Cancer 46, 841–847 (1982). https://doi.org/10.1038/bjc.1982.293
Issue Date:
DOI: https://doi.org/10.1038/bjc.1982.293
This article is cited by
-
Anti-(transforming growth factor ?) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu/nu mice
Cancer Immunology Immunotherapy (1995)
-
Automated measurement of transplantable solid tumors using digital electronic calipers interfaced to a microcomputer
Investigational New Drugs (1990)
-
Die Dopplungszeit des zirkulierenden CEA als individuelles prognostisches Kriterium bei Rezidivierung in Patienten mit gastrointestinalen Karzinomen
Klinische Wochenschrift (1986)
-
In vivo induction of neoplastic growth in nude mouse connective tissue adjacent to xenografted human tumors
Journal of Cancer Research and Clinical Oncology (1983)