Abstract
The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Werther, J., Rivera-MacMurray, S., Bruckner, H. et al. Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome. Br J Cancer 69, 613–616 (1994). https://doi.org/10.1038/bjc.1994.114
Issue Date:
DOI: https://doi.org/10.1038/bjc.1994.114
This article is cited by
-
Breast cancer cells expressing cancer-associated sialyl-Tn antigen have less capacity to develop osteolytic lesions in a mouse model of skeletal colonization
Clinical & Experimental Metastasis (2019)
-
RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells
Gastric Cancer (2016)
-
Regulation of the metastatic cell phenotype by sialylated glycans
Cancer and Metastasis Reviews (2012)
-
Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model
Clinical & Experimental Metastasis (2012)
-
Immunization of Rhesus monkeys with a SialylTn–mAb17-1A conjugate vaccine co-formulated with QS-21 induces a temporary systemic cytokine release and NK cytotoxicity against tumor cells
Cancer Immunology, Immunotherapy (2007)