Abstract
To examine the suggested biological difference between Japanese and British gastric cancers, immunohistochemistry was used to demonstrate eight markers of biological activity in a matched series of 40 Japanese and 33 British cases. There were no differences in the proportions of Japanese and British tumours positive to epidermal growth factor, epidermal growth factor receptor, transforming growth factor alpha, cripto or p53. A significantly greater proportion of British tumours were positive to c-erbB-2 whilst a significantly greater proportion of Japanese tumours were positive to nm23. British tumours had a significantly greater mean proliferating cell nuclear antigen proliferation index than Japanese tumours. These differences could be clinically significant.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Livingstone, J., Yasui, W., Tahara, E. et al. Are Japanese and European gastric cancer the same biological entity? An immunohistochemical study. Br J Cancer 72, 976–980 (1995). https://doi.org/10.1038/bjc.1995.445
Issue Date:
DOI: https://doi.org/10.1038/bjc.1995.445
This article is cited by
-
Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines
Journal of Cancer Research and Clinical Oncology (2017)
-
Prognostic significance of tumor markers in T4a gastric cancer
World Journal of Surgical Oncology (2012)
-
Are biomarkers correlated with recurrence patterns in patients with resectable gastric adenocarcinoma
Molecular Biology Reports (2012)
-
Tyrosine kinases and gastric cancer
Oncogene (2000)