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Paternity after directed collection of testicular sperm for in vitro fertilization after BMT for hematological malignancies

Bone Marrow Transplantation volume 45, pages 1474–1476 (2010)Cite this article

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Allogeneic and autologous BMT are routine treatments for many men with advanced hematologic cancers. Although associated with excellent survival rates, myeloablative conditioning regimens consisting of high-dose combination alkylating agents and TBI in cases of allogenic transplants are generally thought to result in permanent infertility in the vast majority of patients undergoing BMT.1 As a consequence, patients who survive and enter their reproductive years have limited opportunities for fatherhood if they were not old enough to, or able to, bank sperm before induction of therapy.

From our review of the English literature, there are eight reported cases of paternity after BM conditioning and BMT. Seven men established paternity after spontaneous recovery of natural fertility2, 3, 4 and one achieved paternity with the use of assisted reproduction (ART).5 We present two novel cases of biological paternity using testis sperm and assisted reproduction in men without sperm in the ejaculate (azoospermia) after BMT for hematologic malignancies.

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References

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Authors and Affiliations

  1. The Turek Clinic, San Francisco, CA, USA

    A P Ignatov & P J Turek

  2. Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    M S Eisenberg

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  1. A P Ignatov
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  2. M S Eisenberg
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  3. P J Turek
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Correspondence to P J Turek.

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Ignatov, A., Eisenberg, M. & Turek, P. Paternity after directed collection of testicular sperm for in vitro fertilization after BMT for hematological malignancies. Bone Marrow Transplant 45, 1474–1476 (2010). https://doi.org/10.1038/bmt.2009.372

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