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MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer

Cancer Gene Therapy volume 22, pages 291–301 (2015)Cite this article

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Abstract

MicroRNAs (miRNAs), which are small single-stranded RNA molecules composed of 18–23 nucleotides, act as oncogenes or tumor suppressor genes playing important roles in tumor formation, infiltration and metastasis. Subsequently, miRNAs expression contributes to cancer diagnosis and prognosis. Gastric cancer currently has high morbidity and mortality among all malignant tumors, yet it lacks early specific diagnostic markers and effective treatments. In gastric cancer, many studies have detected abnormal expression forms of miRNAs and confirmed their involvement in its tumorigenesis, progression, invasion and metastasis. They may become valuable diagnostic markers and therapeutic targets for gastric cancer. Studying the role of miRNAs in gastric cancer and its relationship with diagnostic and prognostic parameters might help to improve the sensitivity of diagnosis as well as the efficacy of gastric cancer treatment. This review aims to highlight the advancements which might provide new methods for early clinical diagnosis and effective therapeutic options, along with predict response to treatment for gastric cancer.

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Acknowledgements

This work was supported by grant from the Tianshan Talent Project of Xinjiang (No. Y0382067).

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Authors and Affiliations

  1. Department of Thoracic Surgery & Tumor Research Institute, Tianjin Union Medicine Centre, Tianjin, China

    C Jiang

  2. Department of Microbiology & Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing, China

    X Chen

  3. Department of Cardiothoracic Surgery, Zagazig University Hospital, Faculty of Medicine, Zagazig University, Sharkia, Egypt

    M Alattar

  4. Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

    J Wei

  5. Office of Clinical Drug Trial Institution, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China

    H Liu

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  1. C Jiang
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  2. X Chen
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Correspondence to H Liu.

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Jiang, C., Chen, X., Alattar, M. et al. MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer. Cancer Gene Ther 22, 291–301 (2015). https://doi.org/10.1038/cgt.2015.19

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