Abstract
Objectives:
To study the relationship between lipid, fatty acid and lipid-rich food intake and current asthma in a group of Spanish schoolchildren.
Subjects/Methods:
The subjects of this cross-sectional study were 638 Spanish schoolchildren (8–13 years of age). The weight and height of all the subjects were recorded. A questionnaire, completed by the subjects' parents, was used to obtain personal and health information. Current asthma was established when the children had ever had asthma, if they had been diagnosed with asthma by a doctor and if they had been treated with medications at some time in the previous 12 months. Food intake was monitored using a 3-day food record. All foods consumed were converted into energy and nutrients.
Results:
The energy derived from lipids, saturated fatty acids (SFAs) and myristic and palmitic acids was independently associated with current asthma (Odds Ratio (OR) third tertile 2.85 (1.01–8.07) P=0.049, 10.00 (0.89–111.97) P=0.002, 11.21 (1.36–92.24) P=0.002, 7.58 (1.40–41.03) P=0.022, respectively), as was the intake of butter (OR third tertile 2.97 (1.01–8.68) P=0.001). No relationship was seen between this condition and the intake of any other fatty acid, the n-6/n-3 ratio, nor the consumption of margarine, milk products, fish, meat, eggs or vegetable oils.
Conclusions:
Increased intakes of SFAs, myristic and palmitic acids and butter seem to be related to the risk of current asthma in children.
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References
Almqvist C, Garden F, Xuan W, Mihrshahi S, Leeder SR, Oddy W et al. (2007). Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. J Allergy Clin Immunol 119, 1438–1444.
Bacopoulou F, Veltsista A, Vassi I, Gika A, Lekea V, Priftis K et al. (2009). Can we be optimistic about asthma in childhood? A Greek cohort study. J Asthma 46, 171–174.
Black PN, Sharpe S (1997). Dietary fat and asthma: is there a connection? Eur Respir J 10, 6–12.
Bolte G, Winkler G, Hölscher B, Thefeld W, Weiland SK, Heinrich J (2005). Margarine consumption, asthma, and allergy in young adults: results of the German National Health Survey. Ann Epidemiol 15, 207–213.
Bush RK, Peden DB (2009). Advances in environmental and occupational disorders in 2008. J Allergy Clin Immunol 123, 575–578.
Carvajal-Ureña I, García-Marcos L, Busquets-Monge R, Morales-Suárez M, García de Andoni N, Batllés-Garrido J et al. (2005). Variaciones geográficas de la prevalencia de síntomas de asma en niños y adolescentes españoles. International Study of Asthma and Allergies in Childhood (ISAAC) fase III España. Arch Bronconeumol 41, 659–666.
Corbo GM, Forastiere F, De Sario M, Brunetti L, Bonci E, Bugiani M, Sidria-2 Collaborative Group et al. (2008). Wheeze and asthma in children: associations with body mass index, sports, television viewing, and diet. Epidemiology 19, 747–755.
de Luis DA, Izaola O, Aller R, Armentia A, Cuéllar L (2003). Antioxidant and fat intake in patients with pollinic asthma. Med Clin (Barc) 121, 653–654.
de Vries A, Howie SE (2009). Diet and asthma--can you change what you or your children are by changing what you eat? Pharmacol Ther 122, 78–82.
Delmas MC, Guignon N, Leynaert B, Com-Ruelle L, Annesi-Maesano I, Herbet JB et al. (2009). Prevalence of asthma among children in France. Arch Pediatr 16, 1261–1269.
Departamento de Nutrición (UCM) and Alce Ingeniería SA (2009) Available from:http://www.alceingenieria.net/nutricion.htm. (accessed November 1, 2009).
Department of Nutrition (2004a). Food composition tables. In: Ortega RM, López-Sobaler AM, Requejo RM, Andrés P (eds). Food Composition. A Basic Tool for Assessing Nutritional Status. Ed. Complutense: Madrid. pp 15–81.
Department of Nutrition (2004b). Recommended daily intakes of energy and nutrients for the Spanish population. In: Ortega RM, López-Sobaler AM, Requejo RM, Andrés P (eds). Food Composition. A Basic Tool for Assessing Nutritional Status. Madrid: Complutense. pp. 83–84.
Devereux G, Seaton A (2005). Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 115, 1109–1117.
Falcão H, Ramos E, Marques A, Barros H (2008). Prevalence of asthma and rhinitis in 13 year old adolescents in Porto, Portugal. Rev Port Pneumol 14, 747–768.
Fogarty A, Britton J (2000). The role of diet in the aetiology of asthma. Clin Exp Allergy 30, 615–627.
Fumagalli F, Pontes Monteiro J, Sartorelli DS, Vieira MN, de Lourdes Pires Bianchi M (2008). Validation of a food frequency questionnaire for assessing dietary nutrients in Brazilian children 5 to 10 years of age. Nutrition 24, 427–432.
García-Marcos L, Batllés-Garrido J, Blanco-Quirós A, García-Hernández G, Guillén-Grima F, González-Díaz C et al. (2009). Influence of two different geo-climatic zones on the prevalence and time trends of asthma symptoms among Spanish adolescents and schoolchildren. Int J Biometeorol 53, 53–60.
Heinrich J, Hölscher B, Bolte G, Winkler G (2001). Allergic sensitization and diet: ecological analysis in selected European cities. Eur Respir J 17, 395–402.
Huang SL, Pan WH (2001). Dietary fats and asthma in teenagers: analyses of the first Nutrition and Health Survey in Taiwan (NAHSIT). Clin Exp Allergy 31, 1875–1880.
Institute of Medicine, Food and Nutrition Board (2005). Dietary Reference Intakes: Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Washington, DC: National Academy Press.
Kennedy A, Martinez K, Chuang CC, LaPoint K, McIntosh M (2009). Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr 139, 1–4.
Kim JH, Ellwood PE, Asher MI (2009). Diet and asthma: looking back, moving forward. Respir Res 10, 49–56.
Kim JL, Elfman L, Mi Y, Johansson M, Smedje G, Norbäck D (2005). Current asthma and respiratory symptoms among pupils in relation to dietary factors and allergens in the school environment. Indoor Air 15, 170–182.
Laerum BN, Wentzel-Larsen T, Gulsvik A, Omenaas E, Gíslason T, Janson C et al. (2007). Relationship of fish and cod oil intake with adult asthma. Clin Exp Allergy 37, 1616–1623.
Lødrup Carlsen KC, Håland G, Devulapalli CS, Munthe-Kaas M, Pettersen M, Granum B et al. (2006). Asthma in every fifth child in Oslo, Norway: a 10-year follow up of a birth cohort study. Allergy 61, 454–460.
McNeill G, Masson LF, Craig LC, Macdiarmid JI, Holmes BA, Nelson M et al. (2010). Sugar and fat intake among children in Scotland: what is needed to reach the dietary targets? Public Health Nutr 13, 1286–1294.
Mermer C, Mercola J (2002). Omega-3s and childhood asthma. Thorax 57, 281 (Letter to the Editor).
Mikkil V, R L, Laaksonen MM, Juonala M, Viikari J, Pietinen P et al. (2009). Long-term dietary patterns and carotid artery intima media thickness: the cardiovascular Risk in Young Finns Study. Br J Nutr 102, 1507–1512.
Miyake Y, Sasaki S, Arakawa M, Tanaka K, Murakami K, Ohya Y (2008). Fatty acid intake and asthma symptoms in Japanese children: the Ryukyus Child Health Study. Clin Exp Allergy 38, 1644–1650.
Miyamoto S, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Matsunaga I, Osaka Maternal Child Health Study Group et al. (2007). Fat and fish intake and asthma in Japanese women: baseline data from the Osaka Maternal and Child Health Study. Int J Tuberc Lung Dis 11, 103–109.
Mommers M, Gielkens-Sijstermans C, Swaen GMH, van Schayck CP (2005). Trends in the prevalence of respiratory symptoms and treatment in Dutch children over a 12 year period: results of the fourth consecutive survey. Thorax 60, 97–99.
Nagata C, Matsubara T, Fujita H, Nagao Y, Shibuya C, Kashiki Y et al. (2005). Associations of mammographic density with dietary factors in Japanese women. Cancer Epidemiol Biomarkers Prev 14, 2877–2880.
Nagel G, Linseisen J (2005). Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. Eur J Clin Nutr 59, 8–15.
Olsen SF, Østerdal ML, Salvig JD, Mortensen LM, Rytter D, Secher NJ et al. (2008). Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr 88, 167–175.
Ortega RM, Requejo AM, Andrés P, López-Sobaler AM, Redondo R, González-Fernández M (1995). Relationship between diet composition and body mass index in a group of Spanish adolescents. BJN 74, 765–773.
Ortega RM, Requejo AM, López-Sobaler AM (2006). Questionnaires for dietetic studies and the assessment of nutritional status. In: Requejo RM, Ortega R, (eds). Nutriguía. Manual of Clinical Nutrition in Primary Care. Madrid: Complutense. pp. 456–459.
Pala V, Krogh V, Berrino F, Sieri S, Grioni S, Tjønneland A et al. (2009). Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr 90, 602–612.
Quirce S (2009). Asthma in Alergológica-2005. J Investig Allergol Clin Immunol 19, 14–20.
Royo-Bordonada MA, Garcés C, Gorgojo L, Martín-Moreno JM, Lasunción MA, Rodríguez-Artalejo F, Four Provinces Study et al. (2006). Saturated fat in the diet of Spanish children: relationship with anthropometric, alimentary, nutritional and lipid profiles. Public Health Nutr 9, 429–435.
Sistek D, Tschopp JM, Schindler C, Brutsche M, Ackermann-Liebrich U, Perruchoud AP et al. (2001). Clinical diagnosis of current asthma: predictive value of respiratory symptoms in the SAPALDIA study. Swiss Study on Air Pollution and Lung Diseases in Adults. Eur Respir J 17, 214–219.
Stulnig TM (2003). Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. Int Arch Allergy Immunol 132, 310–321.
Tabak C, Wijga AH, de Meer G, Janssen NA, Brunekreef B, Smit HA (2006). Diet and asthma in Dutch school children (ISAAC-2). Thorax 61, 1048–1053.
Takaoka M, Norback D (2008). Diet among Japanese female university students and asthmatic symptoms, infections, pollen and furry pet allergy. Respir Med 102, 1045–1054.
Tavani A, Negri E, La Vecchia C (1996). Food and nutrient intake and risk of cataract. Ann Epidemiol 6, 41–46.
Thompson FE, Subar AF (2008). Dietary Assessment Methodology. In: Coulston AM & Boushey CJ (eds). Nutrition in the Prevention and Treatment of Disease, 2nd edn Elsevier Academy Press: London (UK). pp. 3–39.
Von Mutius E (2009). Gene-environment interactions in asthma. J Allergy Clin Immunol 123, 3–11.
WHO (World Health Organization) (1995). Physical Status: The Use and Interpretation of Anthropometry. Report of the WHO expert committee. WHO technical report series no. 854. WHO: Geneva.
Wijga AH, Smit HA, Kerkhof M, de Jongste JC, Gerritsen J, Neijens HJ et al. (2003). Association of consumption of products containing milk fat with reduced asthma risk in pre-school children: the PIAMA birth cohort study. Thorax 58, 567–572.
Wilson AM, Lewis RD (2004). Disagreement of energy and macronutrient intakes estimated from a food frequency questionnaire and 3-day diet record in girls 4 to 9 years of age. J Am Diet Assoc 104, 373–378.
Wood LG, Gibson PG (2009). Dietary factors lead to innate immune activation in asthma. Pharmacol Ther 123, 37–53.
Woodside JV, McKinley MC, Young IS (2008). Saturated and trans fatty acids and coronary heart disease. Curr Atheroscler Rep 10, 460–466.
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This work was supported by FISS project PI060318.
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Rodríguez-Rodríguez, E., Perea, J., Jiménez, A. et al. Fat intake and asthma in Spanish schoolchildren. Eur J Clin Nutr 64, 1065–1071 (2010). https://doi.org/10.1038/ejcn.2010.127
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DOI: https://doi.org/10.1038/ejcn.2010.127
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