Abstract
Five patients with nephropathic cystinosis were evaluated to assess the ability of topical cysteamine to clear corneal cystine crystals. All patients were randomised to receive topical cysteamine 0.2% six times a day in one eye with normal saline in the other eye as a control.
All five patients showed some improvement in visual symptoms (photophobia, ble-pharospasm and visual acuity) together with an improvement in corneal crystal density. Three of these also had an improvement in Snellen visual acuity and contrast sensitivity.
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Bradbury, J., Danjoux, JP., Voller, J. et al. A randomised placebo-controlled trial of topical cysteamine therapy in patients with nephropathic cystinosis. Eye 5, 755–760 (1991). https://doi.org/10.1038/eye.1991.139
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DOI: https://doi.org/10.1038/eye.1991.139
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