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Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients

Genes & Immunity volume 10, pages 591–595 (2009)Cite this article

Abstract

Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease. Here we present evidence that this polymorphism also predisposes to Wegener's granulomatosis (WG), an autoimmune condition belonging to the group of ANCA (antineutrophil cytoplasmic autoantibody)-associated vasculitides. We found a significant association of the 307Ser allele in separate panels of 520 Northern German (P=0.016, odds ratio (OR)=1.20) and 122 Southern German (P=0.020, OR=1.37) WG cases compared with 1226 healthy controls. The importance of this single-nucleotide polymorphism in the etiopathology of ANCA-associated vasculitides is supported by similar effect sizes that we found in British WG cases (n=105) and German patients with Churg–Strauss syndrome (n=119), which, however, miss significance level because of the relatively small cohorts available for these rare disorders. Finally, we confirm the association with MS in a cohort of 422 German patients (P=0.011, OR=1.23).

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Acknowledgements

Funding: This work was supported by the Deutsche Forschungsgemeinschaft (KFO 170 & Excellence cluster Inflammation at Interfaces Research Areas E and JRG I-h) and a FoRUM grant (F601–2007 to S Wieczorek).

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Authors and Affiliations

  1. Human Genetics, Ruhr University, Bochum, Germany

    S Wieczorek, S Hoffjan, L Rey & J T Epplen

  2. Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany

    A Chan

  3. Division of Immunity and Infection, The Wellcome Trust Clinical Research Facility, University of Birmingham, Edgbaston, Birmingham, UK

    L Harper

  4. Apogenix GmbH, Heidelberg, Germany

    H Fricke

  5. Department of Rheumatology, Vasculitis Center UKSH & Klinikum Bad Bramstedt, University of Lübeck, Lübeck, Germany

    J U Holle, W L Gross & P Lamprecht

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  1. S Wieczorek
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Correspondence to S Wieczorek.

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Wieczorek, S., Hoffjan, S., Chan, A. et al. Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients. Genes Immun 10, 591–595 (2009). https://doi.org/10.1038/gene.2009.44

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  • DOI: https://doi.org/10.1038/gene.2009.44

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