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AMP-activated protein kinase control of energy metabolism in the ischemic heart

International Journal of Obesity volume 32, pages S29–S35 (2008)Cite this article

Abstract

Myocardial ischemia produces an energy-deficient state in heart muscle, which if not corrected can lead to cardiomyocyte death. AMP-activated protein kinase (AMPK) is a key kinase that can increase energy production in the ischemic heart. During ischemia a rapid activation of AMPK occurs, resulting in an activation of both myocardial glucose uptake and glycolysis, as well as an increase in fatty acid oxidation. This activation of AMPK has the potential to increase energy production, thereby protecting the heart during ischemic stress. However, at clinically relevant high levels of fatty acids, ischemia-induced activation of AMPK also stimulates fatty acid oxidation during and following ischemia. This can contribute to ischemic injury secondary to an inhibition of glucose oxidation, which results in a decrease in cardiac efficiency. As a result, AMPK activation has the potential to be either beneficial or harmful in the ischemic heart.

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Acknowledgements

GDL is an Alberta Heritage Foundation for Medical Research Medical Scientist.

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  1. Departments of Pediatrics and Pharmacology, Cardiovascular Research Group, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada

    G D Lopaschuk

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Lopaschuk, G. AMP-activated protein kinase control of energy metabolism in the ischemic heart. Int J Obes 32 (Suppl 4), S29–S35 (2008). https://doi.org/10.1038/ijo.2008.120

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