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Bariatric Surgery

PGC1α gene Gly482Ser polymorphism predicts improved metabolic, inflammatory and vascular outcomes following bariatric surgery

International Journal of Obesity volume 36, pages 363–368 (2012)Cite this article

Abstract

Aims/Hypothesis:

Bariatric surgery is currently employed as an effective approach to treat class III obesity and class II obesity with co-morbidities. Unfortunately, the general anthropometric and metabolic outcomes of the surgery are not homogeneous, and defining the eligibility criteria that allow for a more precise prediction of the outcomes of this invasive procedure will refine the selection of patients. Here we tested the hypothesis that the Gly482Ser polymorphism of the ppargc1a gene would predict different outcomes following bariatric surgery.

Methods:

Fifty-five patients (26 Gly/Gly and 29 Gly/Ser+Ser/Ser) selected for the Roux-en-Y gastric bypass according to the National Institutes of Health Consensus Statement criteria were followed up for 1 year, monitoring their anthropometric, metabolic and inflammatory parameters.

Results:

Patients with the Gly482Ser polymorphism had significantly improved reductions in the waist/hip ratio, fasting blood glucose, C-reactive protein, blood leukocyte count, serum interleukin-6 and intima–media thickness of the carotid artery, as compared with Gly/Gly patients.

Conclusions/Interpretation:

Thus, the Gly482Ser polymorphism may predict a more favorable metabolic and inflammatory outcome for obese patients submitted to bariatric surgery, leading to a reduced atherosclerotic risk.

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Acknowledgements

Grants for these studies were provided by Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). The Laboratory of Cell Signaling is a member of the Instituto Nacional de Ciência e Tecnologia de Obesidade e Diabetes and also a member of the Gastrocentro—University of Campinas. We thank Mr S Shaw for reviewing the English grammar and Mr G Ferraz and Mr A Calixto for technical assistance.

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Authors and Affiliations

  1. Department of Internal Medicine, Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil

    S R Geloneze, J Morari & L A Velloso

  2. Department of Internal Medicine, Laboratory of Investigation on Metabolism and Diabetes, University of Campinas, Campinas, Brazil

    B Geloneze, J R Matos-Souza & M M Lima

  3. Department of Surgery, University of Campinas, Campinas, Brazil

    E A Chaim & J C Pareja

Authors
  1. S R Geloneze
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  2. B Geloneze
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  3. J Morari
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  4. J R Matos-Souza
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  5. M M Lima
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  6. E A Chaim
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Correspondence to L A Velloso.

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Author contributions

SRG and JM conducted research; JRM-S performed the Doppler and echocardiography studies; MML performed the clamp studies; EAC and JCP performed the gastric bypass surgeries; BG planned some of the experiments and coordinated the clamp studies and the clinical assistance to the patients; LAV designed the research, wrote the paper and had final responsibility for the final content.

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Geloneze, S., Geloneze, B., Morari, J. et al. PGC1α gene Gly482Ser polymorphism predicts improved metabolic, inflammatory and vascular outcomes following bariatric surgery. Int J Obes 36, 363–368 (2012). https://doi.org/10.1038/ijo.2011.176

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  • DOI: https://doi.org/10.1038/ijo.2011.176

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