Abstract
The Centers for Disease Control and Prevention released its third set of nationally representative data on serum levels of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and non-ortho and coplanar polychlorinated biphenyls (PCBs) in the United States collected during the 2003–2004 sampling period as part of the National Health and Nutrition Examination Survey (NHANES). We utilize the serum PCDD/F data from the three NHANES sampling periods spanning 1999–2004 to assess whether there are discernable temporal trends in the United States, either for the overall population or by age. We also compare population serum data to biomonitoring equivalents (BEs) derived for PCDDs/Fs/PCBs; BEs are estimates of the concentration of PCDD/Fs/PCBs corresponding to existing exposure guidance values estimated by various governmental agencies. The serum PCDD/F data from 1999 to 2004 provide evidence that levels in the US population are declining, mirroring international trends, although the lower levels are principally observable in the 2003–2004 time period. Examining the trend by population age, from the 1999 to 2004, PCDD/F serum levels decreased by 56% for the 12-to 19-year-old group and by 38% for the 20-to 39-year olds. A slight nonsignificant decrease was observed for 40-to 59-year olds and a slight significant increase was found for 60+ year olds. Interpretation of the data across time is complicated by certain aspects of the data unique to the various sampling time periods; thus, caution should be exercised when evaluating trend information. The population mean PCDD/F/PCB TEQ is approximately equal to the BE based on the Agency for Toxic Substances and Disease Registry's Minimum Risk Level and is approximately 2–4 times lower than the remaining BEs, placing the population mean at the border between medium and low priority levels. However, certain segments of the population have levels at the medium/high priority level (e.g., the 95th percentiles for ages 60 years and older).
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References
Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Chlorinated Dibenzo-p-dioxins. http://www.atsdr.cdc.gov/toxprofiles/tp104.html#bookmark14, 1999.
Aylward L.L., Brunet R.C., Carrier G., Hays S.M., Cushing C.A., Needham L.L., et al. Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort. J Expo Anal Environ Epidemiol 2005: 15 (1): 51–65.
Aylward L.L., LaKind J.S., and Hays S.M. Derivation of biomonitoring equivalents (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context. J Toxicol Environ Health A 2008: 71 (22): 1499–1508.
Bates M.N., Buckland S.J., Garrett N., Ellis H., Needham L.L., Patterson D.G. Jr, et al. Persistent organochlorines in the serum of the non-occupationally exposed New Zealand population. Chemosphere 2004: 54 (10): 1431–1443.
Centers for Disease Control and Prevention. Second National Report on Human Exposure to Environmental Chemicals. Atlanta, GA: CDC, 2003.
Centers for Disease Control and Prevention. Third National Report on Human Exposure to Environmental Chemicals. Atlanta, GA: CDC, 2005: http://www.cdc.gov/exposurereport/report.htm.
European Commission Scientific Committee on Foods (ECSCF). Opinion of the Scientific Committee on Food on the risk assessment of dioxins and dioxin-like PCBs in food. Update based on new scientific information available since the adoption of the SCF opinion of 22nd November 2000 2001 Rep. CS/CNTM/DIOXIN/20 final. http://europa.eu.int/comm/food/fs/sc/scf/out90_en.pdf (No. CS/CNTM/DIOXIN/20 final). Brussels, Belgium: European Commission.
Ferriby L.L., Knutsen J.S., Harris M., Unice K.M., Scott P., Nony P., et al. Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001–2002 National Health and Nutrition Examination Survey of the United States population. J Expo Sci Environ Epidemiol 2007: 17 (4): 358–371.
Harden F.A., Toms L.M., Paepke O., Ryan J.J., and Müller J.F. Evaluation of age, gender and regional concentration differences for dioxin-like chemicals in the Australian population. Chemosphere 2007: 67 (9): S318–S324.
Hays S.M., and Aylward L.L. Dioxin risks in perspective: past, present, and future. Regul Toxicol Pharmacol 2003: 37 (2): 202–217.
Hays S.M., Becker R.A., Leung H.W., Aylward L.L., and Pyatt D.W. Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective. Regul Toxicol Pharmacol 2007: 47 (1): 96–109.
Hays S.M., Aylward L.L., LaKind J.S., Bartels M.J., Barton H.A., Boogaard P.J., Brunk C., DiZio S., Dourson M., Goldstein D.A., Lipscomb J., Kilpatrick M.E., Krewski D., Krishnan K., Nordberg M., Okino M., Tan Y.M., Viau C., and Yager J.W. Guidelines for the derivation of biomonitoring equivalents: report from the Biomonitoring Equivalents Expert Workshop. Reg Toxicol Pharmacol 2008: 51 (3 Suppl): S4–S15.
Joint FAO/WHO Expert Committee on Food Additives (JECFA). Fifty-Seventh Meeting Rome, 5–14 June 2001. Summary and Conclusions 2001 (No. http://www.who.int/ipcs/food/jecfa/summaries/en/summary_57.pdf).
Kreuzer P.E., Csanády G.A., Baur C., Kessler W., Päpke O., Greim H., et al. TCDD and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with as special emphasis on its uptake by nutrition. Arch Toxicol 1997: 71 (6): 383–400.
LaKind J.S., Berlin C., and Naiman D.Q. Infant exposure to chemicals in breast milk in the United States: what we need to learn from a breast milk monitoring program. Environ Health Perspect 2001: 109: 75–88.
LaKind J.S. Recent global trends and physiologic origins of dioxins and furans in human milk. J Exposure Sci Environ Epidemiol 2007: 17: 510–524.
LaKind J.S., Aylward L.L., Brunk C., DiZio S., Dourson M., Goldstein D.A., Kilpatrick M.E., Krewski D., Bartels M.J., Barton H.A., Boogaard P.J., Lipscomb J., Krishnan K., Nordberg M., Okino M., Tan Y.M., Viau C., Yager J.W., and Hays S.M. Guidelines for the communication of biomonitoring equivalents: report from the Biomonitoring Equivalents Expert Workshop. Reg Toxicol Pharmacol 2008: 51 (3 Suppl): S16–S26.
Lorber M. A pharmacokinetic model for estimating exposure of Americans to dioxin-like compounds in the past, present, and future. Sci Total Environ 2002: 288 (1–2): 81–95.
Needham L.L., Barr D.B., Caudill S.P., Pirkle J.L., Turner W.E., Osterloh J., et al. Concentrations of environmental chemicals associated with neurodevelopmental effects in US population. Neurotoxicology 2005: 26: 531–545.
Needham L.L., Naiman D.Q., Patterson D.G. Jr, and LaKind J.S. Assigning concentration values for dioxin and furan congeners in human serum when measurements are below limits of detection: an observational approach. Chemosphere 2007: 67 (3): 439–447.
Patterson D.G. Jr, Canady R., Wong L.-Y., Lee R., Turner W., Caudill S., et al. Age specific dioxin TEQ reference range. Organohalogen Compounds 2004: 66: 2878–2883.
Patterson D.G. Jr, Turner W.E., Caudill S.P., and Needham L.L. Total TEQ reference range (PCDDs, PCDFs, cPCBs, mono-PCBs) for the US population 2001–2002. Chemosphere 2008: 73 (1 Suppl): S261–S277.
Rier S.E., Turner W.E., Martin D.C., Morris R., Lucier G.W., and Clark G.C. Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis. Toxicol Sci 2001: 59 (1): 147–159.
United Kingdom Committee on Toxicology (UKCOT). Statement on the tolerable daily intake for dioxins and dioxin-like polychlorinated biphenyls. http://www.food.gov.uk/science/ouradvisors/toxicity/statements/cotstatements2001/dioxinsstate, 2001.
Van den Berg M., Birnbaum L., Bosveld A.T., Brunström B., Cook P., Feeley M., et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 1998: 106 (12): 775–792.
Van den Berg M., Birnbaum L.S., Denison M., De Vito M., Farland W., Feeley M., et al. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 2006: 93 (2): 223–241.
Wong L.Y., Millette M.D., Uddin M.S., Needham L.L., Patterson D.G., Turner W., et al. Serum dioxin levels in residents of Calcasieu and Lafayette parishes, Louisiana with comparison to the US population. J Expo Sci Environ Epidemiol 2008: 18 (3): 252–261.
Acknowledgements
Dr. LaKind, Mr. Hays, and Ms. Aylward received support for this research from the American Chemistry Council (ACC). We thank Dr. Larry Needham, CDC, for his thoughts and suggestions on the paper. The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of ACC. ACC was not involved in the design, collection, management, analysis, or interpretation of the data; or in the preparation or approval of the paper.
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Lakind, J., Hays, S., Aylward, L. et al. Perspective on serum dioxin levels in the United States: an evaluation of the NHANES data. J Expo Sci Environ Epidemiol 19, 435–441 (2009). https://doi.org/10.1038/jes.2008.63
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DOI: https://doi.org/10.1038/jes.2008.63
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