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Maternal serum and cord blood preptin levels in gestational diabetes mellitus

Journal of Perinatology volume 31, pages 350–355 (2011)Cite this article

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Abstract

Objective:

To assess preptin concentrations in pregnant women with and without gestational diabetes mellitus (GDM) and in the cord blood of their fetuses.

Study Design:

In all, 31 pregnant women with GDM and 31 gestational age-matched healthy pregnant subjects participated. Maternal serum and cord blood preptin levels were measured with ELISA. The relationships between maternal serum and cord blood preptin levels, anthropometric and metabolic parameters were also assessed.

Result:

Maternal serum and cord blood preptin levels were found higher in patients with GDM compared with control pregnant women. Preptin concentration in maternal serum was positively correlated with maternal age, fasting insulin levels, 1-h blood glucose after glucose load and cord preptin concentrations at birth. However, relationships between maternal and/or cord serum preptin and fetal growth parameters at birth were not detected.

Conclusion:

Our results indicate that preptin concentrations increase in maternal serum of women with GDM. Preptin levels may provide a novel approach to identify women with GDM.

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Authors and Affiliations

  1. Department of Pediatrics, Inonu University School of Medicine, Malatya, Turkey

    M Aslan, N Karsavuran, D G Dogan & E Botan

  2. Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey

    O Celik & A Kafkasli

  3. Malatya State Hospital Beydagi Campus Biochemistry, Malatya, Turkey

    N Celik

Authors
  1. M Aslan
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  2. O Celik
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  3. N Karsavuran
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  4. N Celik
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  5. D G Dogan
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  6. E Botan
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  7. A Kafkasli
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Corresponding author

Correspondence to D G Dogan.

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The authors declare no conflict of interest.

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Aslan, M., Celik, O., Karsavuran, N. et al. Maternal serum and cord blood preptin levels in gestational diabetes mellitus. J Perinatol 31, 350–355 (2011). https://doi.org/10.1038/jp.2010.125

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  • DOI: https://doi.org/10.1038/jp.2010.125

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