Abstract
Objective:
Develop a risk prediction model for severe intraventricular hemorrhage (IVH) in very low birth weight infants (VLBWI).
Study Design:
Prospectively collected data of infants with birth weight 500 to 1249 g born between 2001 and 2010 in centers from the Neocosur Network were used. Forward stepwise logistic regression model was employed. The model was tested in the 2011 cohort and then applied to the population of VLBWI that received prophylactic indomethacin to analyze its effect in the risk of severe IVH.
Result:
Data from 6538 VLBWI were analyzed. The area under ROC curve for the model was 0.79 and 0.76 when tested in the 2011 cohort. The prophylactic indomethacin group had lower incidence of severe IVH, especially in the highest-risk groups.
Conclusion:
A model for early severe IVH prediction was developed and tested in our population. Prophylactic indomethacin was associated with a lower risk-adjusted incidence of severe IVH.
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Acknowledgements
We thank all the Neocosur centers that participated in this study.
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Appendix
Appendix
The present study included the following collaborators from the Neocosur Network: Argentina: Guillermo Colantonio, Jorge Zapata, Gaston Perez, Susana Garcia Ana Pedraza (Clinica y Maternidad Suizo Argentina, Buenos Aires); Isabel Kurlat, Oscar Di Siervi, Adriana Escarate (Hospital de Clinicas Jose de San Martin); Gonzalo Mariani, Jose Maria Ceriani, Silvia Fernandez, Carlos Fustiñana, Pablo Brener, Eleonora Edwards (Hospital Italiano, Buenos Aires); Jorge Tavosnaska, Liliana Roldan, Hector Sexer, Gladys Saa, Debora Sabatelli, Maria Laura Gendra, Maria Fernanda Buraschi, Paula Molina (Hospital Juan Fernandez, Buenos Aires); Daniel Agost, Federico Morganti, Adriana Fontana, Daniela Chandias, Monica Rinaldi (Hospital Lagomaggiore, Mendoza); Carlos Grandi, Elio Rojas, Claudio Solana, Ricardo Nieto, Javier Meritano, Miguel Larguia, Laura Kasten, Lucrecia Cuneo (Maternidad Sarda, Buenos Aires); Marcelo Decaro, Lionel Cracco, Gustavo Bassi, Noemi Jacobi, Andrea Brum, Nestor Vain (Sanatorio de la Trinidad, Buenos Aires); Adriana Aguilar, Miriam Guerrero, Edgardo Szyld, Alcira Escandar (Hospital Dr Diego Paroissien, Buenos Aires); Daniel Abdala, Martin Guida, Lucila Ferrin, Horacio Roge (Hospital Español de Mendoza); Gabriel Musante, Maria C. Capelli, Juan Pablo Berazategui, Magdalena de Elizalde, Juan Ignacio Fraga, Rodolfo Keller (Hospital Universitario Austral, Buenos Aires); Luis Ahumada, Mirta Ferreyra (Hospital Nuestra Señora de la Misericordia, Cordoba). Brasil: Vanda Ferreira, Roberta Borges, Marynea Do Vale, Silvia Cavalcante, Joama Gusmão, Patricia Franco, Maria Jose Silva (Hospital Universidad Federal de Maranhão, Sao Luis). Chile: Jorge Fabres, Alberto Estay, Alvaro Gonzalez, Jose Luis Tapia, Javier Kattan, Mariela Quezada, Soledad Urzua (Hospital Clinico Universidad Catolica de Chile, Santiago); Rodrigo Ramirez, Maria Eugenia Hübner, Jaime Burgos, Jorge Catalan (Hospital Clinico Universidad de Chile, Santiago); Lilia Campos, Lilian Cifuentes, Jorge Leon, Roxana Aguilar, Sergio Treuer, Jimena Giaconi, Aldo Bancalari (Hospital Guillermo Grant, Concepcion); Jane Standen, Marisol Escobar, Viviana Veas, Daniela Sandino (Hospital Gustavo Fricke, Viña del Mar); Agustina Gonzalez, Claudia Avila, Carla Guzman (Hospital San Jose, Santiago); Claudia Toro, Patricia Mena, Beatriz Milet, Enrica Pittaluga (Hospital Dr Sotero del Rio, Santiago); Veronica Peña, Rafael Mendizabal, Dagoberto Pizarro (Hospital San Borja Arriaran, Santiago); Ivonne D’Apremont, Guillermo Marshall, Luis Villarroel, Mariela Quezada, Angelica Dominguez (Unidad Base de Datos, Pontificia Universidad Catolica, Santiago). Paraguay: Jose Lacarruba, Elizabeth Cespedes, Ramon Mir, Elvira Mendieta, Larissa Genes, Carlos Caballero (Departamento de Hospital de Clinicas de Asuncion). Peru: Veronica Webb, Fabiola Rivera, Margarita Llontop, Sicilia Bellomo, Jaime Zegarra (Hospital Cayetano Heredia, Lima); Oscar Chumbes, Anne Castañeda, Walter Cabrera, Raul Llanos, Jorge Mucha, Gustavo Garcia (Hospital Guillermo Almenara, Lima). Uruguay: Beatriz Ceruti, Daniel Borbonet, Sandra Gugliucci, Ana Lain, Mariza Martinez, Gabriela Bazan, Susana Piffaretti, Isabel Cuña, Patricia Bermudez (Facultad de Medicina Servicio de Recien Nacidos, Montevideo).
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Luque, M., Tapia, J., Villarroel, L. et al. A risk prediction model for severe intraventricular hemorrhage in very low birth weight infants and the effect of prophylactic indomethacin. J Perinatol 34, 43–48 (2014). https://doi.org/10.1038/jp.2013.127
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DOI: https://doi.org/10.1038/jp.2013.127
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