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Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. A prospective randomized clinical trial

Abstract

Objective:

To compare the efficacy of clonidine versus phenobarbital in reducing morphine sulfate treatment days for neonatal abstinence syndrome (NAS).

Study Design:

Prospective, non-blinded, block randomized trial at a single level III NICU (Neonatal Intensive Care Unit). Eligible infants were treated with a combination of medications as per protocol. Primary outcome was treatment days with morphine sulfate. Secondary outcomes were the mean total morphine sulfate dose, outpatient phenobarbital days, adverse events and treatment failures.

Results:

A total of 82 infants were eligible, of which 68 were randomized with 34 infants in each study group. Adjusting for covariates phenobarbital as compared with clonidine had shorter morphine sulfate treatment days (−4.6, 95% confidence interval (CI): −0.3, −8.9; P=0.037) with no difference in average morphine sulfate total dose (1.1 mg kg−1, 95% CI: −0.1, 2.4; P=0.069). Post-discharge phenobarbital was continued for an average of 3.8 months (range 1 to 8 months). No other significant differences were noted.

Conclusion:

Phenobarbital as adjunct had clinically nonsignificant shorter inpatient but significant overall longer therapy time as compared with clonidine.

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Acknowledgements

We acknowledge the support provided by the Department of Pediatrics in funding our trial, Ms Tammy Sears for her role as a research assistant on the project, Mr Gerald Korona and the investigational pharmacy team at Baystate Medical Center and the invaluable support of the Davis Neonatal Intensive Care Unit nursing staff, without whose exceptional support the project could not have been completed. This work was funded by the Department of Pediatrics, Baystate Children’s Hospital.

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Correspondence to R Singh.

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Supplementary Information accompanies the paper on the Journal of Perinatology website

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Surran, B., Visintainer, P., Chamberlain, S. et al. Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. A prospective randomized clinical trial. J Perinatol 33, 954–959 (2013). https://doi.org/10.1038/jp.2013.95

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