Research ArticleSOX2 contributes to melanoma cell invasion
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Keywords
invasion
melanoma
matrix metalloproteinase-3
SOX2
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These are co-senior authors.
The mechanisms of melanoma invasion are poorly understood. The embryonic stem cell transcription factor Sox2 coincides with matrix metalloproteinase-3 expression at the invading interface with dermal stroma. Sox2 is shown to be essential for melanoma invasion and positively correlates with matrix metalloproteinase-3 expression.
© 2012 United States & Canadian Academy of Pathology.