Articleβ-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines
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β-adrenoceptors
immunohistochemistry
melanoma
melanoma progression
norepinephrine/epinephrine
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Both β1- and β2-adrenoceptors are significantly up-regulated in malignant melanoma compared to melanocytic naevi, and stimulation of melanoma cell lines with norepinephrine orepinephrine causes them to increase proteolytic invasiveness and secrete pro-tumorigenic cytokines. These data suggest that circulating norepinephrine and epinephrine affect melanoma progression in vivo, at least in part through the β-adrenoceptor activation.
© 2013 United States & Canadian Academy of Pathology.