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The role of microRNA in human leukemia: a review

Leukemia volume 23, pages 1257–1263 (2009)Cite this article

Abstract

MicroRNAs (miRNAs or miRs) are 18–22-nucleotide non-coding RNAs that have emerged as a new paradigm of epigenetic regulation in both normal development and cellular function, and in the pathogenesis of human disease including cancer. This review summarizes the current literature of mechanism of gene regulation by miRNA and their role in hematopoiesis and leukemogenesis. An understanding of these processes suggests further avenues for research to understand gene regulation and miRNA-based therapeutic approaches.

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Acknowledgements

Dr Calin is supported as a Fellow of The University of Texas MD Anderson Research Trust, as a Fellow of University of Texas System Regents Research Scholar and as a Ladjevardian Regents Research Scholar Fund. This study was also funded by an Institutional Research Grant and by a CCSG Award to George A Calin.

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  1. Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA

    S Yendamuri

  2. Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    G A Calin

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Yendamuri, S., Calin, G. The role of microRNA in human leukemia: a review. Leukemia 23, 1257–1263 (2009). https://doi.org/10.1038/leu.2008.382

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