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Performance of the myelofibrosis secondary to PV and ET-prognostic model (MYSEC-PM) in a series of 262 patients from the Spanish registry of myelofibrosis

Leukemia volume 32, pages 553–555 (2018)Cite this article

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Accurate disease risk assessment is crucial for treatment decision making in myelofibrosis (MF), with this particularly applying to younger patients who might be candidates for allogeneic hematopoietic stem cell transplantation (allo-HSCT).1, 2 For such purpose, several prognostic models are widely used in clinical practice.3, 4, 5 Though these models were derived from patients with de novo or primary MF (PMF), they are also applied to patients with MF secondary to essential thrombocythemia (PET MF) or polycythemia vera (PPV MF), despite data suggesting a poorer prognostic accuracy in this setting.6, 7 Recently, Passamonti et al.8 have developed a new prognostic model to specifically address the prediction of survival in patients with secondary MF, the Myelofibrosis Secondary to PV and ET-Prognostic Model (MYSEC-PM). It is worth noting that this prognostic model has not yet been tested in an independent series of patients.

We aimed to investigate the performance of the MYSEC-PM, as compared with the International Prognostic Scoring System (IPSS),3 in a nationwide series of 262 patients with secondary MF from the Spanish Registry of Myelofibrosis. We did not test the dynamic IPSS (DIPSS) and DIPSS-plus prognostic models as comparators because the former was optimized for prognostication during disease’s evolution whereas the second requires cytogenetic examination that is lacking in many MF patients because of bone marrow dry taps.

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Acknowledgements

This work was supported by the Grant RD12/0036/0010 from the Instituto de Salud Carlos III, Spanish Ministry of Health.

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Authors and Affiliations

  1. Hematology Department, Hospital Clínico, Valencia, Spain

    J-C Hernández-Boluda & M Gómez

  2. Transfusion Service, Hospital Clínic, Barcelona, Spain

    A Pereira

  3. Hematology Department, Hospital Clínic, Barcelona, Spain

    J-G Correa & F Cervantes

  4. Hematology Department, Hospital del Mar, Barcelona, Spain

    A Alvarez-Larrán

  5. Hematology and Medical Oncology Department, Hospital Morales Meseguer, Murcia, Spain

    F Ferrer-Marín

  6. Hematology Department, Hospital Universitario de Canarias, Tenerife, Spain

    J-M Raya

  7. Hematology Department, Hospital 12 de Octubre, Madrid, Spain

    J Martínez-López

  8. Hematology Department, Hospital Clínico, Santiago de Compostela, Spain

    M Pérez-Encinas

  9. Hematology Department, Hospital Germans Trias i Pujol, Badalona, Spain

    N Estrada

  10. Hematology Department, Hospital Duran i Reynals, Hospitalet de Llobregat, Spain

    P Velez

  11. Hematology Department, Hospital Vall d'Hebron, Barcelona, Spain

    M-L Fox

  12. Hematology Department, Hospital Ramón y Cajal, Madrid, Spain

    V García-Gutiérrez

  13. Hematology Department, Hospital Universitario Central de Asturias, Oviedo, Spain

    A Payer

  14. Hematology Department, Hospital La Paz, Madrid, Spain

    A Kerguelen

  15. Hematology Department, Hospital Universitario de Burgos, Burgos, Spain

    B Cuevas

  16. Hematology Department, Hospital Son Espases, Mallorca, Spain

    M-A Durán

  17. Hematology Department, Hospital de Jerez, Cádiz, Spain

    M-J Ramírez

  18. Hematology Department, Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain

    M-T Gómez-Casares

  19. Hematology Department, Hospital Costa del Sol, Marbella, Spain

    M-I Mata-Vázquez

  20. Hematology Department, Hospital La Fe, Valencia, Spain

    E Mora

  21. Hematology Department, Hospital Sant Pau, Barcelona, Spain

    C Martínez-Valverde

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  1. J-C Hernández-Boluda
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  22. M Gómez
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  23. F Cervantes
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on behalf of the Grupo Español de Enfermedades Mieloproliferativas Filadelfia Negativas (GEMFIN)

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Correspondence to J-C Hernández-Boluda.

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Hernández-Boluda, JC., Pereira, A., Correa, JG. et al. Performance of the myelofibrosis secondary to PV and ET-prognostic model (MYSEC-PM) in a series of 262 patients from the Spanish registry of myelofibrosis. Leukemia 32, 553–555 (2018). https://doi.org/10.1038/leu.2017.297

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