Elsevier

Mucosal Immunology

Volume 3, Issue 3, May 2010, Pages 260-269
Mucosal Immunology

Article
Human primary gastric dendritic cells induce a Th1 response to H. pylori

https://doi.org/10.1038/mi.2010.10Get rights and content
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Abstract

Adaptive CD4 T-cell responses are important in the pathogenesis of chronic Helicobacter pylori gastritis. However, the gastric antigen-presenting cells that induce these responses have not yet been identified. Here we show that dendritic cells (DCs) are present in the gastric mucosa of healthy subjects and are more prevalent and more activated in the gastric mucosa of H. pylori-infected subjects. H. pylori induced gastric DCs isolated from noninfected subjects to express increased levels of CD11c, CD86 and CD83, and to secrete proinflammatory cytokines, particularly interleukin (IL)-6 and IL-8. Importantly, gastric DCs pulsed with live H. pylori, but not control DCs, mediated T-cell secretion of interferon-γ. The ability of H. pylori to induce gastric DC maturation and stimulate gastric DC activation of Th1 cells implicates gastric DCs as initiators of the immune response to H. pylori.

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Supplementary information The online version of this article (doi:10.1038/mi.2010.10) contains supplementary material, which is available to authorized users.