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Metabolism of stromal and immune cells in health and disease

Nature volume 511, pages 167–176 (2014)Cite this article

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Abstract

Cancer cells have been at the centre of cell metabolism research, but the metabolism of stromal and immune cells has received less attention. Nonetheless, these cells influence the progression of malignant, inflammatory and metabolic disorders. Here we discuss the metabolic adaptations of stromal and immune cells in health and disease, and highlight how metabolism determines their differentiation and function.

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Figure 1: Endothelial cell metabolism.
Figure 2: Fibroblast metabolism.
Figure 3: T-cell metabolism.
Figure 4: Macrophage metabolism.

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Acknowledgements

Supporting fellowships: FWO Fellowships (B.G., B.W.W., A.K.) and Marie Curie Fellowship (B.W.W.). Supporting grants: IUAP P7/03, long-term structural funding - Methusalem funding by the Flemish Government, FWO grants, AXA Research Fund and ERC Advanced Research Grant. We thank P. Agostinis, M. Baes, K. De Bock, S. Fendt, P. Fraisl, B. Lambrecht, A. Liston, M. Mazzone, J. Rathmell, J. Van Ginderachter, P. Verstreken and others for suggestions.

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  1. Department of Oncology, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, University of Leuven, Leuven B-3000, Belgium,

    Bart Ghesquière, Brian W. Wong, Anna Kuchnio & Peter Carmeliet

  2. Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B-3000, Belgium,

    Bart Ghesquière, Brian W. Wong, Anna Kuchnio & Peter Carmeliet

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  1. Bart Ghesquière
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Correspondence to Peter Carmeliet.

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Ghesquière, B., Wong, B., Kuchnio, A. et al. Metabolism of stromal and immune cells in health and disease. Nature 511, 167–176 (2014). https://doi.org/10.1038/nature13312

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