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Immunology

The chronicles of T-cell exhaustion

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T cells of the immune system often fail to target cancer cells because they enter a dysfunctional state known as exhaustion. Molecular analysis of T-cell exhaustion provides insights into the clinical use of these cells.

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Figure 1: Temporary reversal of T-cell exhaustion.

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References

  1. Jiang, Y., Li, Y. & Zhu, B. Cell Death Dis. 6, e1792 (2015).

    Article  CAS  Google Scholar 

  2. Pauken, K. E. et al. Science 354, 1160–1165 (2016).

    Article  ADS  CAS  Google Scholar 

  3. Sen, D. R. et al. Science 354, 1165–1169 (2016).

    Article  ADS  CAS  Google Scholar 

  4. Wherry, E. J. Nature Immunol. 12, 492–499 (2011).

    Article  CAS  Google Scholar 

  5. Wherry, E. J. et al. Immunity 27, 670–684 (2007).

    Article  CAS  Google Scholar 

  6. Topalian, S. L. et al. J. Clin. Oncol. 32, 1020–1030 (2014).

    Article  CAS  Google Scholar 

  7. Wherry, E. J. & Kurachi, M. Nature Rev. Immunol. 15, 486–499 (2015).

    Article  CAS  Google Scholar 

  8. Odorizzi, P. M., Pauken, K. E., Paley, M. A., Sharpe, A. & Wherry, E. J. J. Exp. Med. 212, 1125–1137 (2015).

    Article  CAS  Google Scholar 

  9. Doering, T. A. et al. Immunity 37, 1130–1144 (2012).

    Article  CAS  Google Scholar 

  10. Schietinger, A., Delrow, J. J., Basom, R. S., Blattman, J. N. & Greenberg, P. D. Science 335, 723–727 (2012).

    Article  ADS  CAS  Google Scholar 

  11. Bengsch, B. & Wherry, E. J. Immunity 42, 203–205 (2015).

    Article  CAS  Google Scholar 

  12. Jones, P. A., Issa, J.-P. J. & Baylin, S. Nature Rev. Genet. 17, 630–641 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Robert A. Amezquita or Susan M. Kaech.

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Amezquita, R., Kaech, S. The chronicles of T-cell exhaustion. Nature 543, 190–191 (2017). https://doi.org/10.1038/nature21508

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