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Illuminating Parkinson's therapy with optogenetics

Nature Biotechnology volume 33, pages 149–150 (2015)Cite this article

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Controlling transplanted dopamine neurons with light helps define their mechanism of action.

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Figure 1: Dopamine neurons engineered to express HALO release dopamine, which binds to D1 receptors and regulates glutamatergic inputs to GABA neurons, thereby restoring the motor function of grafted mice.

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Authors and Affiliations

  1. Yuejun Chen, Man Xiong and Su-Chun Zhang are at the Waisman Center, University of Wisconsin, Madison, Wisconsin, USA.,

    Yuejun Chen, Man Xiong & Su-Chun Zhang

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  1. Yuejun Chen
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  2. Man Xiong
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  3. Su-Chun Zhang
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Correspondence to Su-Chun Zhang.

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Chen, Y., Xiong, M. & Zhang, SC. Illuminating Parkinson's therapy with optogenetics. Nat Biotechnol 33, 149–150 (2015). https://doi.org/10.1038/nbt.3140

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