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Networks and crosstalk: integrin signalling spreads

Nature Cell Biology volume 4, pages E65–E68 (2002)Cite this article

Multicellular organisms must coordinate signals from adhesion receptors with those from other signalling receptors (for example, growth factor receptors). Here, we briefly review paradigms of integrin–adhesion-receptor signalling. We discuss how adhesive signalling is coordinately regulated through intersecting networks. We also examine some examples of how some forms of integrin crosstalk may lead to unforeseen and potentially deleterious responses.

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Figure 1: Integrins can intersect the MAP kinase pathway at multiple points.

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Acknowledgements

Research from our laboratories was supported by grants from the NIH. This is publication number 14702-VB from the Scripps Research Institute.

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  1. Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, 92037, California, USA

    Martin A. Schwartz & Mark H. Ginsberg

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  1. Martin A. Schwartz
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  2. Mark H. Ginsberg
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Schwartz, M., Ginsberg, M. Networks and crosstalk: integrin signalling spreads. Nat Cell Biol 4, E65–E68 (2002). https://doi.org/10.1038/ncb0402-e65

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