Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin αvβ3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
NUMB suppression by miR-9-5P enhances CD44+ prostate cancer stem cell growth and metastasis
Scientific Reports Open Access 27 May 2021
-
Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
Nature Communications Open Access 21 June 2016
-
Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling
Cell Death & Disease Open Access 21 April 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chong, C. R. & Janne, P. A. Nat. Med. 19, 1389–1400 (2013).
Nguyen, L. V., Vanner, R., Dirks, P. & Eaves, C. J. Nat. Rev. Cancer 12, 133–143 (2012).
Seguin, L. et al. Nat. Cell Biol. 16, 457–468 (2014).
Hu, Y. & Smyth, G. K. J. Immunol. Methods 347, 70–78 (2009).
Pao, W. et al. PLoS Med. 2, e73 (2005).
Liou, G-Y. & Storz, P. Free Radical Res. 44, 479–496 (2010).
Giordano, C. R. et al. Exp. Cell Res. 318, 2014–2021 (2012).
Kim, J. Y. et al. Proc. Natl Acad. Sci. USA 110, 12414–12419 (2013).
O'Hare, T., Zabriskie, M. S., Eiring, A. M. & Deininger, M. W. Nat. Rev. Cancer 12, 513–526 (2012).
Smith, C. C. et al. Nature 485, 260–263 (2012).
Li, J. et al. Mol. Syst. Biol. 9, 705 (2013).
Medema, J. P. Nat. Cell Biol. 15, 338–344 (2013).
Baylin, S. B. & Jones, P. A. Nat. Rev. Cancer 11, 726–734 (2011).
Gazin, C., Wajapeyee, N., Gobeil, S., Virbasius, C. M. & Green, M. R. Nature 449, 1073–1077 (2007).
Author information
Authors and Affiliations
Contributions
N.K. and L.V.N. contributed equally to this work.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Kannan, N., Nguyen, L. & Eaves, C. Integrin β3 links therapy resistance and cancer stem cell properties. Nat Cell Biol 16, 397–399 (2014). https://doi.org/10.1038/ncb2960
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb2960
This article is cited by
-
NUMB suppression by miR-9-5P enhances CD44+ prostate cancer stem cell growth and metastasis
Scientific Reports (2021)
-
Implementation of a Precision Pathology Program Focused on Oncology-Based Prognostic and Predictive Outcomes
Molecular Diagnosis & Therapy (2017)
-
Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
Nature Communications (2016)
-
Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling
Cell Death & Disease (2016)
-
Synchronized cell attachment triggered by photo-activatable adhesive ligands allows QCM-based detection of early integrin binding
Scientific Reports (2015)
