Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate
Cell Death & Disease Open Access 15 December 2022
-
Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer
BMC Cancer Open Access 24 February 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Warfel, N. A. & El-Deiry, W. S. Curr. Opin. Oncol. 25, 52–58 (2013).
Romanov, V. S., Pospelov, V. A. & Pospelova, T. V. Biochemistry (Mosc) 77, 575–584 (2012).
Li, T. et al. Cell 149, 1269–1283 (2012).
Viale, A. et al. Nature 457, 51–56 (2009).
Marhenke, S. et al. Gut 63, 1501–1512 (2014).
Abbas, T. & Dutta, A. Nat. Rev. Cancer 9, 400–414 (2009).
Galanos, P. et al. Nat. Cell Biol. 18, 777–789 (2016).
Mailand, N., Gibbs-Seymour, I. & Bekker-Jensen, S. Nat. Rev. Mol. Cell Biol. 14, 269–282 (2013).
Dutto, I., Tillhon, M., Cazzalini, O., Stivala, L. A. & Prosperi, E. Arch. Toxicol. 89, 155–178 (2015).
Burrell, R. A. et al. Nature 494, 492–496 (2013).
Alderton, F., Humphrey, P. P. & Sellers, L. A. Mol. Pharmacol. 59, 1119–1128 (2001).
Rudalska, R. et al. Nat. Med. 20, 1138–1146 (2014).
Choudhury, A. R. et al. Nat. Genet. 39, 99–105 (2007).
Jaiswal, S. et al. N. Engl. J. Med. 371, 2488–2498 (2014).
Martincorena, I. et al. Science 348, 880–886 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Romanov, V., Rudolph, K. p21 shapes cancer evolution. Nat Cell Biol 18, 722–724 (2016). https://doi.org/10.1038/ncb3382
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3382
This article is cited by
-
Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate
Cell Death & Disease (2022)
-
Cytotoxic effect of green synthesized silver nanoparticles in MCF7 and MDA-MB-231 human breast cancer cells in vitro
The Nucleus (2020)
-
Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer
BMC Cancer (2017)
