Abstract
Approximately 25–40% of men who undergo radical retropubic prostatectomy (RRP) for the treatment of clinically localized prostate cancer will experience biochemical recurrence. A rapid prostate-specific antigen (PSA) doubling time or high-grade disease are risk factors for progression to bone metastases and cancer-specific mortality. Salvage external-beam radiotherapy (EBRT) to the prostate fossa is the only curative therapy for patients with biochemical recurrence after RRP, but it is used relatively infrequently to treat recurrent prostate cancer because of a widespread perception that most patients have systemic recurrence, and its reported lack of efficacy for high-risk disease. However, in a large, multicenter study of patients who received salvage EBRT for a rising PSA level after RRP, a substantial proportion of patients with high-grade disease and/or a rapid PSA doubling time were observed to have a favorable outcome after salvage EBRT if it was administered at low PSA values. This suggests that salvage EBRT could provide long-term cancer control for patients at the highest risk of progression to bone metastases and cancer-specific mortality. A nomogram that predicts the 3-year progression-free probability after salvage EBRT has been developed to facilitate the selection of patients for this potentially curative therapy. In the absence of other curative therapies, all patients with recurrent prostate cancer should be considered for salvage EBRT, particularly those with positive surgical margins. To be successful, salvage EBRT should be administered at the earliest evidence of recurrent disease, once a rising PSA trend as been confirmed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Brandeis J et al. (2000) A nationwide charge comparison of the principal treatments for early stage prostate carcinoma. Cancer 89: 1792–1799
Moul JW (2000) Prostate specific antigen only progression of prostate cancer. J Urol 163: 1632–1642
Hull GW et al. (2002) Cancer control with radical prostatectomy alone in 1,000 consecutive patients. J Urol 167: 528–534
Han M et al. (2001) Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience. Urol Clin North Am 28: 555–565
Roehl KA et al. (2004) Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. J Urol 172: 910–914
Stamey TA et al. (1999) Biological determinants of cancer progression in men with prostate cancer. JAMA 281: 1395–1400
Zincke H et al. (1994) Long-term (15 years) results after radical prostatectomy for clinically localized (stage T2c or lower) prostate cancer. J Urol 152: 1850–1857
American Society for Therapeutic Radiology and Oncology Consensus Panel (1997) Consensus statement: guidelines for PSA following radiation therapy. Int J Radiat Oncol Biol Phys 37: 1035–1041
Amling CL et al. (2001) Defining prostate specific antigen progression after radical prostatectomy: what is the most appropriate cut point? J Urol 165: 1146–1151
Patel A et al. (1997) Recurrence patterns after radical retropubic prostatectomy: clinical usefulness of prostate specific antigen doubling times and log slope prostate specific antigen. J Urol 158: 1441–1445
Pound CR et al. (1999) Natural history of progression after PSA elevation following radical prostatectomy. Jama 281: 1591–1597
Roberts SG et al. (2001) PSA doubling time as a predictor of clinical progression after biochemical failure following radical prostatectomy for prostate cancer. Mayo Clin Proc 76: 576–581
D'Amico AV et al. (2003) Surrogate end point for prostate cancer-specific mortality after radical prostatectomy or radiation therapy. J Natl Cancer Inst 95: 1376–1383
Holzbeierlein JM et al. (2004) Complications of androgen deprivation therapy: prevention and treatment. Oncology (Huntingt) 18: 303–309
Krupski TL et al. (2004) Natural history of bone complications in men with prostate carcinoma initiating androgen deprivation therapy. Cancer 101: 541–549
Ornstein DK et al. (1998) Evaluation and management of men whose radical prostatectomies failed: results of an international survey. Urology 52: 1047–1054
Partin AW et al. (1994) Evaluation of serum prostate-specific antigen velocity after radical prostatectomy to distinguish local recurrence from distant metastases. Urology 43: 649–659
Mehta SS et al. (2004) Patterns of secondary cancer treatment for biochemical failure following radical prostatectomy: data from CaPSURE. J Urol 171: 215–219
Holmberg L et al. A (2002) randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer. N Engl J Med 347: 781–789
Leventis AK et al. (2001) Local recurrence after radical prostatectomy: correlation of US features with prostatic fossa biopsy findings. Radiology 219: 432–439
Raj GV et al. (2002) Clinical utility of indium 111-capromab pendetide immunoscintigraphy in the detection of early, recurrent prostate carcinoma after radical prostatectomy. Cancer 94: 987–996
Lightner DJ et al. (1990) Prostate specific antigen and local recurrence after radical prostatectomy. J Urol 144: 921–926
Leventis AK et al. (2001) Prediction of response to salvage radiation therapy in patients with prostate cancer recurrence after radical prostatectomy. J Clin Oncol 19: 1030–1039
Sella T et al. (2004) Suspected local recurrence after radical prostatectomy: endorectal coil MR imaging. Radiology 231: 379–385
Stephenson AJ et al. (2004) Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy. JAMA 291: 1325–1332
Song DY et al. (2002) Salvage radiotherapy for rising or persistent PSA after radical prostatectomy. Urology 60: 281–287
Pisansky TM et al. (2000) Radiotherapy for isolated serum prostate specific antigen elevation after prostatectomy for prostate cancer. J Urol 163: 845–850
Koppie TM et al. (2001) Is anastomotic biopsy necessary before radiotherapy after radical prostatectomy? J Urol 166: 111–115
Thomas CT et al. (2003) Indium-111-capromab pendetide radioimmunoscintigraphy and prognosis for durable biochemical response to salvage radiation therapy in men after failed prostatectomy. J Clin Oncol 21: 1715–1721
Cher ML et al. (1998) Limited role of radionuclide bone scintigraphy in patients with prostate specific antigen elevations after radical prostatectomy. J Urol 160: 1387–1391
Katz MS et al. (2003) Predictors of biochemical outcome with salvage conformal radiotherapy after radical prostatectomy for prostate cancer. J Clin Oncol 21: 483–489
Cadeddu JA et al. (1998) Long-term results of radiation therapy for prostate cancer recurrence following radical prostatectomy. J Urol 159: 173–177
Vicini FA et al. (1999) Treatment outcome with adjuvant and salvage irradiation after radical prostatectomy for prostate cancer. Urology 54: 111–117
Valicenti RK et al. (1998) Durable efficacy of early postoperative radiation therapy for high-risk pT3N0 prostate cancer: the importance of radiation dose. Urology 52: 1034–1040
Maier J et al. (2004) Salvage radiation for a rising PSA following radical prostatectomy. Urol Oncol 22: 50–56
Cox JD et al. (1999) Consensus statements on radiation therapy of prostate cancer: guidelines for prostate re-biopsy after radiation and for radiation therapy with rising prostate-specific antigen levels after radical prostatectomy. American Society for Therapeutic Radiology and Oncology Consensus Panel. J Clin Oncol 17: 1155
Anscher MS et al. (2000) Radiotherapy for a rising prostate-specific antigen after radical prostatectomy: the first 10 years. Int J Radiat Oncol Biol Phys 48: 369–375
Wu JJ et al. (1995) The efficacy of postprostatectomy radiotherapy in patients with an isolated elevation of serum prostate-specific antigen. Int J Radiat Oncol Biol Phys 32: 317–323
Zelefsky MJ et al. (2002) High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys 53: 1111–1116
Zelefsky MJ et al. (1998) Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer. Int J Radiat Oncol Biol Phys 41: 491–500
Stephenson AJ et al. (2003) Predicting the outcome of salvage radiotherapy for suspected local recurrence of prostate cancer after radical prostatectomy [abstract 1577]. In: Proceedings of the American Society of Clinical Oncology 39th Annual Meeting: May 30–June 3 2003; Chicago, IL, 392 (Ed. Marshall JL) Alexandria, VA: American Society of Clinical Oncology
Bolla M et al. (2004) Does postoperative radiotherapy after radical prostatectomy improve progression-free survival in pT3N0 prostate cancer? [abstract 4540]. In: Proceedings of the American Society of Clinical Oncology 40th Annual Meeting: June 5–8 2004; New Orleans LA, 382 (Ed. Grunberg SM) Alexandria, VA: American Society of Clinical Oncology
Chawla AK et al. (2002) Salvage radiotherapy after radical prostatectomy for prostate adenocarcinoma: analysis of efficacy and prognostic factors. Urology 59: 726–731
Liauw SL et al. (2003) Salvage radiotherapy for biochemical failure of radical prostatectomy: a single-institution experience. Urology 61: 1204–1210
Van Cangh PJ et al. (1998) Adjuvant radiation therapy does not cause urinary incontinence after radical prostatectomy: results of a prospective randomized study. J Urol 159: 164–166
Acknowledgements
AJ Stephenson is supported in part by the American Foundation for Urologic Disease, a training grant (T32-82088) from the National Institutes of Health, and a gift from the Tina and Richard V. Carolan Foundation.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Stephenson, A., Slawin, K. The value of radiotherapy in treating recurrent prostate cancer after radical prostatectomy. Nat Rev Urol 1, 90–96 (2004). https://doi.org/10.1038/ncpuro0056
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/ncpuro0056
This article is cited by
-
Salvage radiation therapy following radical prostatectomy in Stockholm County in 2008–2016
Journal of Radiation Oncology (2019)
-
Targeted prostate biopsy and MR-guided therapy for prostate cancer
Abdominal Radiology (2016)
-
Radiation therapy for prostate cancer after prostatectomy: adjuvant or salvage?
Nature Reviews Urology (2011)