Abstract
IT is now recognized that hydroxylated metabolites of vitamin D (that is, cholecalciferol) function as effectors of the physiological actions originally attributed to the unaltered vitamin1. The activation of vitamin D by specific hydroxylation reactions and sequestration of the resultant metabolites by target tissues represents a hormonal control loop which is feed-back sensitive. 25-Hydroxycholecalciferol (25-HCC) and 1,25-dihydroxycholecalciferol (1,25-DHCC) have been shown to be participants in the control loop, vitamin D being first metabolized in the liver to 25-HCC2 which in turn is hydroxylated in the C-1 position to 1,25-DHCC in the kidney3,4. The metabolically active form in the intestine appears to be 1,25-DHCC5,6.
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OMDAHL, J., GRAY, R., BOYLE, I. et al. Regulation of Metabolism of 25-Hydroxycholecalciferol by Kidney Tissue in vitro by Dietary Calcium. Nature New Biology 237, 63–64 (1972). https://doi.org/10.1038/newbio237063a0
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DOI: https://doi.org/10.1038/newbio237063a0
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