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The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

Nature Genetics volume 14, pages 33–41 (1996)Cite this article

Abstract

The recurrent translocation t(8;16)(p11 ;p13) is a cytogenetic hallmark for the M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated genes. Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein. At the chromosome 8 breakpoint we identify a novel gene, MOZ, which encodes a 2,004-amino-acid protein characterized by two C4HC3 zinc fingers and a single C2HC zinc finger in conjunction with a putative acetyltransferase signature. In-frame MOZ–CBP fusion transcripts combine the MOZ finger motifs and putative acetyltransferase domain with a largely intact CBP. We suggest that MOZ may represent a chromatin-associated acetyltransferase, and raise the possibility that a dominant MOZ–CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation.

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Authors and Affiliations

  1. Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Julian Borrow, Vincent P. Stanton Jr, J. Michael Andresen & David E. Housman

  2. West German Cancer Center, Hufelandstr55, 45122, Essen, 1, Germany

    Reinhard Becher

  3. St.Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38101, USA

    Frederick G. Behm

  4. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA

    Raju S. K. Chaganti

  5. The John Hopkins Oncology Center, 600 N.Wolfe Street, Baltimore, Maryland, 21287, USA

    Curt I. Civin

  6. University of Washington Medical Center, Seattle, Washington, 98195, USA

    Christine Disteche

  7. Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, Toronto, M4N 3M5, Canada

    Ian Dubé

  8. Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London, WC2 A3PX, UK

    Anna Marie Frischauf

  9. British Columbia Cancer Agency, 600 West 1 Oth Avenue, Vancouver, British Columbia, V5Z 4E6, Canada

    Doug Horsman

  10. Department of Clinical Genetics, University Hospital, S-22185, Lund, Sweden

    Felix Mitelman

  11. Universita'delgi Studi, Via Borsari 46, 44100, Ferrara, Italy

    Stefano Volinia

  12. Centre for Human Genetics, 117 Manchester Road, Sheffield, S10 5DN, UK

    Ann E. Watmore

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Borrow, J., Stanton, V., Andresen, J. et al. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein. Nat Genet 14, 33–41 (1996). https://doi.org/10.1038/ng0996-33

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