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Variation in FTO contributes to childhood obesity and severe adult obesity

Nature Genetics volume 39, pages 724–726 (2007)Cite this article

A Corrigendum to this article was published on 01 October 2007

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Abstract

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 × 10−26 in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

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Figure 1: LD structure and association in the FTO region.

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Change history

  • 26 September 2007

    In the version of this article initially published, the authors failed to acknowledge that recruitment of obese cases was supported by both Assistance-Publique Hôpitaux de Paris and Centre National de la Recherche Scientifique. This error has been corrected in the PDF version of the article.

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Acknowledgements

The authors thank M. Deweirder and F. Allegaert for DNA preparation and D.-A. Tregouet for discussions on statistics. This study was supported by the ANR Diabomics grant from the French National Agency for Research. Work on the German replication data set was supported by grants from the DFG (KFO 152: “Atherobesity”, project KO 3512/1–1 (TP 1) to A.K. and 1264/10–1 (TP5) to W.K.) and from the EC (“PIONEER” integrated project grant to W.K.). The Leipzig Schoolchildren project was supported by unrestricted grants from Pfizer Pharma and Novo Nordisk (W.K.).

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Authors and Affiliations

  1. CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France

    Christian Dina, David Meyre, Sophie Gallina, Emmanuelle Durand, Vincent Vatin, Cecile Lecoeur, Jérome Delplanque, Emmanuel Vaillant, Stéphane Cauchi, Jean-Claude Chèvre & Philippe Froguel

  2. University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany

    Antje Körner & Wieland Kiess

  3. Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

    Peter Jacobson & Lena M S Carlsson

  4. INSERM U859, Université de Lille 2, Lille, France

    François Pattou

  5. Diabétologie et Métabolisme, Centre Hospitalier Universitaire Vaudois (CHUV) BH19, Lausanne, Switzerland

    Juan Ruiz

  6. Paediatric Endocrine Unit, Jeanne de Flandre Hospital, Lille, France

    Jacques Weill

  7. INSERM U690, Robert Debre Hospital, Paris, France

    Claire Levy-Marchal

  8. Klinik Lindberg, Winterthur, Switzerland

    Fritz Horber & Natascha Potoczna

  9. INSERM, U557, Bobigny, France

    Serge Hercberg

  10. Institut Scientifique de Recherche Agronomique (INRA), U1125, Bobigny, France

    Serge Hercberg

  11. Conservatoire National des Arts et Métiers (CNAM), Paris, EA3200, France

    Serge Hercberg

  12. Paris 13 University, Bobigny, France

    Serge Hercberg

  13. Centre de Recherche en Nutrition Humaine (CRNH) Ile de France, Bobigny, France

    Serge Hercberg

  14. Department of Pediatric Endocrinology and INSERM U561, Saint Vincent de Paul Hospital, René Descartes University, Paris, France

    Catherine Le Stunff & Pierre Bougnères

  15. Department of Internal Medicine III and Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany

    Peter Kovacs

  16. Department of Diabetology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

    Michel Marre

  17. INSERM U780-IFR69, Villejuif, France

    Beverley Balkau

  18. Université Paris-Sud, Villejuif, France

    Beverley Balkau

  19. Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK

    Philippe Froguel

Authors
  1. Christian Dina
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  2. David Meyre
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  3. Sophie Gallina
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  4. Emmanuelle Durand
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  5. Antje Körner
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  6. Peter Jacobson
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  7. Lena M S Carlsson
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  8. Wieland Kiess
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  9. Vincent Vatin
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  10. Cecile Lecoeur
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  11. Jérome Delplanque
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  12. Emmanuel Vaillant
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  13. François Pattou
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  14. Juan Ruiz
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  15. Jacques Weill
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  16. Claire Levy-Marchal
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  17. Fritz Horber
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  18. Natascha Potoczna
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  19. Serge Hercberg
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  20. Catherine Le Stunff
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  21. Pierre Bougnères
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  22. Peter Kovacs
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  23. Michel Marre
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  24. Beverley Balkau
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  25. Stéphane Cauchi
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  26. Jean-Claude Chèvre
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  27. Philippe Froguel
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Contributions

Contributions of each author are detailed in the Supplementary Note online.

Corresponding author

Correspondence to Christian Dina.

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Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

LD in the FTO gene. (PDF 63 kb)

Supplementary Fig. 2

FTO gene expression in human tissues. (PDF 83 kb)

Supplementary Table 1

Assessment of putative functionality of SNPs. (PDF 40 kb)

Supplementary Table 2

Genotype distribution and association tests under the general and additive models. (PDF 43 kb)

Supplementary Table 3

Genotype counts, Hardy Weinberg tests and failed genotype rate. (PDF 36 kb)

Supplementary Table 4

Effect size estimation and quantitative trait associations. (PDF 42 kb)

Supplementary Table 5

Description of study populations. (PDF 32 kb)

Supplementary Table 6

LD with potentially associated SNPs. (PDF 38 kb)

Supplementary Methods (PDF 81 kb)

Supplementary Notes (PDF 62 kb)

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Dina, C., Meyre, D., Gallina, S. et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39, 724–726 (2007). https://doi.org/10.1038/ng2048

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