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Mechanisms maintaining peripheral tolerance

Nature Immunology volume 11, pages 21–27 (2010)Cite this article

Abstract

The presentation of self-peptide–MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide–MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide–MHC and threaten the health of the individual.

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Figure 1: DC maturation model.

Marina Corral

Figure 2: Control of T cell responsiveness by DCs.

Marina Corral

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Acknowledgements

Supported by the US National Institutes of Health (P01 AI35296 and R01 AI080764).

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  1. Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    Daniel L Mueller

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Mueller, D. Mechanisms maintaining peripheral tolerance. Nat Immunol 11, 21–27 (2010). https://doi.org/10.1038/ni.1817

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