Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Organ-specific regulation of innate immunity

Nature Immunology volume 8, pages 3–4 (2007)Cite this article

Immune responses to microbial challenge in various tissues are not the same. Organ-specific immune responses are adapted to maintain organ physiology.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Janeway, C.A., Jr. & Medzhitov, R. Annu. Rev. Immunol. 20, 197–216 (2002).

    Article  CAS  Google Scholar 

  2. Lee, C.A. Infect. Agents Dis. 5, 1–7 (1996).

    CAS  PubMed  Google Scholar 

  3. Takeda, K., Kaisho, T. & Akira, S. Annu. Rev. Immunol. 21, 335–376 (2003).

    Article  CAS  Google Scholar 

  4. Hoebe, K., Janssen, E. & Beutler, B. Nat. Immunol. 5, 971–974 (2004).

    Article  CAS  Google Scholar 

  5. Takabayshi, K. et al. Immunity 24, 475–487 (2006).

    Article  CAS  Google Scholar 

  6. Hayashi, T. et al. J. Clin. Invest. 114, 270–279 (2004).

    Article  CAS  Google Scholar 

  7. Cross, A.S. J. Endotoxin Res. 8, 83–98 (2002).

    CAS  PubMed  Google Scholar 

  8. Smythies, L.E. et al. J. Clin. Invest. 115, 66–75 (2005).

    Article  CAS  Google Scholar 

  9. Hertz, C.J. et al. J. Immunol. 171, 6820–6826 (2003).

    Article  CAS  Google Scholar 

  10. Pivarcsi, A. et al. Int. Immunol. 15, 721–730 (2003).

    Article  CAS  Google Scholar 

  11. Han, J. & Ulevitch, R.J. Nat. Immunol. 6, 1198–1205 (2005).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

I thank R. Seder (Vaccine Research Center, US National Institutes of Health), S. Datta and M. Corr (University of California San Diego) for their useful comments and L. Beck for editorial assistance. Supported by the National Institutes of Health (AI40682, AI57709 and HL79449).

Author information

Authors and Affiliations

  1. Department of Medicine 0663, University of California San Diego, La Jolla, 92093, California, USA

    Eyal Raz

Authors
  1. Eyal Raz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Raz, E. Organ-specific regulation of innate immunity. Nat Immunol 8, 3–4 (2007). https://doi.org/10.1038/ni0107-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0107-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing