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Mitochondrial control of the NLRP3 inflammasome

Nature Immunology volume 12, pages 199–200 (2011)Cite this article

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During the past few decades, the vital and lethal functions of mitochondria have been investigated extensively. Data now demonstrate that these organelles also regulate the innate immune response by modulating inflammasome-mediated generation of proinflammatory cytokines.

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Figure 1: Mitochondrial death and danger signaling.

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Authors and Affiliations

  1. Oliver Kepp and Lorenzo Galluzzi are with Institut National de la Santé et de la Recherche Médicale, U848, Villejuif, France, Institut Gustave Roussy, Villejuif, France, and Université Paris-Sud, Villejuif, France.,

    Oliver Kepp & Lorenzo Galluzzi

  2. Guido Kroemer is with Institut National de la Santé et de la Recherche Médicale, U84s8, Villejuif, France, Metabolomics Platform, Institut Gustave Roussy, Villejuif, France, Centre de Recherche des Cordeliers, Paris, France, Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France, and Université Paris Descartes, Paris, France.,

    Guido Kroemer

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  1. Oliver Kepp
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  2. Lorenzo Galluzzi
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  3. Guido Kroemer
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Correspondence to Guido Kroemer.

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The authors declare no competing financial interests.

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Kepp, O., Galluzzi, L. & Kroemer, G. Mitochondrial control of the NLRP3 inflammasome. Nat Immunol 12, 199–200 (2011). https://doi.org/10.1038/ni0311-199

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