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Cross-priming

Nature Immunology volume 7, pages 363–365 (2006)Cite this article

The stimulation of antigen-specific CD8+ T cells by the presentation of antigen acquired from outside the cell was the startling conclusion of Michael Bevan's work done more than 30 years ago.

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References

  1. Zinkernagel, R.M. & Doherty, P.C. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature 251, 547–548 (1974).

    Article  CAS  Google Scholar 

  2. Shearer, G.M., Rehn, T.G. & Garbarino, C.A. Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex. J. Exp. Med. 141, 1348–1364 (1975).

    Article  CAS  Google Scholar 

  3. Snell, G.D., Wheeler, N. & Aaron, M. A new method of typing inbred strains of mice for histocompatibility antigens. Transplant. Bull. 4, 18–21 (1957).

    CAS  PubMed  Google Scholar 

  4. Bevan, M.J. Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier. Nature 256, 419–421 (1975).

    Article  CAS  Google Scholar 

  5. Gordon, R., Simpson, E. & Samelson, L. In vitro cell-mediated immune responses to the male specific (H-Y) antigen in mice. J. Exp. Med. 142, 1108–1120 (1975).

    Article  CAS  Google Scholar 

  6. Bevan, M.J. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143, 1283–1288 (1976).

    Article  CAS  Google Scholar 

  7. Bevan, M.J., Langman, R.E. & Cohn, M. H-2 antigen-specific cytotoxic T cells induced by concanavalin A: estimation of their relative frequency. Eur. J. Immunol. 6, 150–156 (1976).

    Article  CAS  Google Scholar 

  8. Bevan, M.J. Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming. J. Immunol. 117, 2233–2238 (1976).

    CAS  PubMed  Google Scholar 

  9. Bevan, M.J. Priming for a cytotoxic response to minor histocompatibility antigens: antigen specificity and failure to demonstrate a carrier effect. J. Immunol. 118, 1370–1374 (1977).

    CAS  Google Scholar 

  10. Carbone, F.R. & Bevan, M.J. Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J. Exp. Med. 171, 377–387 (1990).

    Article  CAS  Google Scholar 

  11. Bevan, M.J. Antigen recognition. Class discrimination in the world of immunology. Nature 325, 192–194 (1987).

    Article  CAS  Google Scholar 

  12. den Haan, J.M., Lehar, S.M. & Bevan, M.J. CD8+ but not CD8− dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192, 1685–1696 (2000).

    Article  CAS  Google Scholar 

  13. Iyoda, T. et al. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195, 1289–1302 (2002).

    Article  CAS  Google Scholar 

  14. Heath, W.R. & Carbone, F.R. Cross-presentation in viral immunity and self-tolerance. Nat. Rev. Immunol. 1, 126–134 (2001).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, Howard Hughes Medical Center, University of Washington, Seattle, 98195, Washington, USA

    Michael J Bevan

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  1. Michael J Bevan
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Bevan, M. Cross-priming. Nat Immunol 7, 363–365 (2006). https://doi.org/10.1038/ni0406-363

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