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The nucleolus: at the stem of immortality

Nature Medicine volume 9, pages 24–25 (2003)Cite this article

A nucleolar protein, nucleostemin, is now implicated in the control of stem and cancer cell proliferation. Nucleostemin may modulate p53 function through shuttling between the nucleolus and the nucleoplasm.

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Figure 1: Nucleostemin (brown) stains nucleoli in the nuclei (green) of cells in the embryonic rat brain.

Tsai and McKay, reprinted with permission from Genes and Development

Figure 2: Nucleostemin may regulate p53 function through shuttling between the nucleolus and nucleoplasm.

Renee Lucas

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Authors and Affiliations

  1. Molecular Biology Program and Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Rosa Bernardi & Pier Paolo Pandolfi

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  1. Rosa Bernardi
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  2. Pier Paolo Pandolfi
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Correspondence to Pier Paolo Pandolfi.

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Bernardi, R., Pandolfi, P. The nucleolus: at the stem of immortality. Nat Med 9, 24–25 (2003). https://doi.org/10.1038/nm0103-24

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