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Bone marrow does not contribute substantially to endothelial-cell replacement in transplant arteriosclerosis

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Figure 1: Origin of endothelial cells after aortic allografting in BM chimeric rats.

References

  1. Takahashi, T. et al. Ischemia- and cytokine-induced mobilization of bone-marrow derived endothelial progenitor cells for neovascularization. Nature Med. 5, 434–438 (1999).

    Article  CAS  Google Scholar 

  2. Dimmeler, S. et al. HMG-CoA reductase inhibitors (statins) increase endothelial pogenitor cells via the PI 3-kinase/Akt pathway. J. Clin. Invest. 108, 391–397 (2001).

    Article  CAS  Google Scholar 

  3. Rafii, S. Circulating endothelial precursors: mystery, reality, and promise. J. Clin. Invest. 105, 17–19 (2000).

    Article  CAS  Google Scholar 

  4. Hillebrands, J.L. et al. Origin of neointimal endothelium and α-actin-positive smooth muscle cells in transplant arteriosclerosis. J. Clin. Invest. 107, 1411–1422 (2001).

    Article  CAS  Google Scholar 

  5. Medawar, P.B. Transplantation of tissues and organs: introduction. Br. Med. Bull. 21, 97–99 (1965).

    Article  Google Scholar 

  6. Lagaaij, E.L. et al. Endothelial cell chimerism after renal transplantation and vascular rejection. Lancet 357, 33–37 (2001).

    Article  CAS  Google Scholar 

  7. Shimizu, K. et al. Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy. Nature Med. 7, 738–741 (2001).

    Article  CAS  Google Scholar 

  8. Li, J. et al. Vascular smooth muscle cells of recipient origin mediate intimal expansion after aortic allotransplantation in mice. Am. J. Pathol. 158, 1943–1947 (2001).

    Article  CAS  Google Scholar 

  9. Dignat-George, F. & Sampol, J. Circulating endothelial cells in vascular disorders: new insights into an old concept. Eur. J. Haematol. 65, 215–220 (2000).

    Article  CAS  Google Scholar 

  10. Lin, Y., Weisdorf, D.J., Solovey, A. & Hebbel, R.P. Origins of circulating endothelial cells and endothelial outgrowth from blood. J. Clin. Invest. 105, 71–77 (2000).

    Article  CAS  Google Scholar 

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Hillebrands, JL., Klatter, F., van Dijk, W. et al. Bone marrow does not contribute substantially to endothelial-cell replacement in transplant arteriosclerosis. Nat Med 8, 194–195 (2002). https://doi.org/10.1038/nm0302-194

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