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Interleukin-33 safeguards neutrophils in sepsis

Cytokines have a fundamental role in orchestrating innate immune responses to bacterial infections. Interleukin-33 (IL-33) is now shown to protect from sepsis by promoting neutrophil influx into the focus of infection (pages 708–712).

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Figure 1: IL-33 promotes the migration of neutrophils into the focus of infection.

Kimberly Caesar

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Correspondence to Thierry Calandra.

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Roger, T., Calandra, T. Interleukin-33 safeguards neutrophils in sepsis. Nat Med 16, 638–639 (2010). https://doi.org/10.1038/nm0610-638

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