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Heart failure

Mitochondrial dysfunction and oxidative stress in CHF

Nature Reviews Cardiology volume 12, pages 6–8 (2015)Cite this article

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The results of the Q-SYMBIO trial showing a reduction in mortality in patients with heart failure treated with coenzyme Q10 have substantial limitations. Nevertheless, they highlight the need to identify effective new therapies targeted at mitochondrial dysfunction and oxidative stress in heart failure.

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Figure 1: Oxidative stress and mitochondrial dysfunction in the failing heart.

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Acknowledgements

The authors are supported by funding from the British Heart Foundation.

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Authors and Affiliations

  1. Cardiovascular Division, King's College London British Heart Foundation Centre of Excellence, Denmark Hill Campus, 125 Coldharbour Lane, London, SE5 9NU, UK

    Darlington O. Okonko & Ajay M. Shah

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  1. Darlington O. Okonko
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Correspondence to Ajay M. Shah.

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The authors declare no competing financial interests.

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Okonko, D., Shah, A. Mitochondrial dysfunction and oxidative stress in CHF. Nat Rev Cardiol 12, 6–8 (2015). https://doi.org/10.1038/nrcardio.2014.189

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