Despite favourable results in pivotal clinical trials involving novel direct oral anticoagulants, vitamin K antagonists remain the most commonly prescribed anticoagulant. Newer oral anticoagulants are slated for a wide range of additional indications, and specific antidotes to neutralize associated bleeding complications are currently under development.
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Vitamin K antagonists: relative strengths and weaknesses vs. direct oral anticoagulants for stroke prevention in patients with atrial fibrillation
Journal of Thrombosis and Thrombolysis Open Access 28 November 2016
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Fareed, J. Making headway in anticoagulant and antiplatelet therapy. Nat Rev Cardiol 12, 70–71 (2015). https://doi.org/10.1038/nrcardio.2014.222
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DOI: https://doi.org/10.1038/nrcardio.2014.222
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