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Valvular disease

Functional mitral regurgitation: should all valves be replaced?

An Author Correction to this article was published on 02 July 2020

This article has been updated

In the first multicentre, randomized trial to compare undersized annuloplasty versus mitral replacement in severe ischaemic mitral regurgitation (MR), higher recurrence of clinically significant MR and increased rehospitalization occurred after repair. With the rapid development of transcatheter mitral valve interventions, valve replacement might be the preferable transcatheter mitral valve therapy.

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Figure 1: Pathophysiology of functional mitral regurgitation.

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  • 02 July 2020

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

References

  1. De Bonis, M. et al. Recurrence of mitral regurgitation parallels the absence of left ventricular reverse remodeling after mitral repair in advanced dilated cardiomyopathy. Ann. Thorac. Surg. 85, 932–939 (2008).

    Article  Google Scholar 

  2. Goldstein, D. et al. Two-year outcomes of surgical treatment of severe ischemic mitral regurgitation. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1512913 (2015).

  3. Maisano, F. et al. The future of transcatheter mitral valve interventions: competitive or complementary role of repair versus replacement? Eur. Heart J. 36, 1651–1659 (2015).

    Article  Google Scholar 

  4. Taramasso, M. et al. Interventional versus surgical mitral valve therapy. Which technique for which patient? Herz 38, 460–466 (2013).

    Article  CAS  Google Scholar 

  5. Dayan, V., Soca, G., Cura, L. & Mestres, C. A. Similar survival after mitral valve replacement or repair for ischemic mitral regurgitation: a meta-analysis. Ann. Thorac. Surg. 97, 758–765 (2014).

    Article  Google Scholar 

  6. Puvimanasinghe, J. P. et al. Prognosis after aortic valve replacement with a bioprosthesis: predictions based on meta-analysis and microsimulation. Circulation 103, 1535–1541 (2001).

    Article  CAS  Google Scholar 

  7. Vesey, J. M. & Otto, C. M. Complications of prosthetic heart valves. Curr. Cardiol. Rep. 6, 106–111 (2004).

    Article  Google Scholar 

  8. Hammermeister, K. et al. Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial. J. Am. Coll. Cardiol. 36, 1152–1158 (2000).

    Article  CAS  Google Scholar 

  9. Butchart, E. G. et al. Recommendations for the management of patients after heart valve surgery. Eur. Heart J. 26, 2463–2471 (2005).

    Article  Google Scholar 

  10. Vahanian, A. et al. Guidelines on the management of valvular heart disease Eur. Heart J. 33, 2451–2496 (2012).

    Article  Google Scholar 

Download references

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Correspondence to Francesco Maisano.

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Taramasso, M., Maisano, F. Functional mitral regurgitation: should all valves be replaced?. Nat Rev Cardiol 13, 65–66 (2016). https://doi.org/10.1038/nrcardio.2015.206

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