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Neurodegenerative disease

Diabetes, microvascular pathology and Alzheimer disease

Nature Reviews Neurology volume 5, pages 305–306 (2009)Cite this article

Epidemiological studies suggest that the risk of developing cognitive impairment and dementia is increased in individuals with diabetes mellitus, although the evidence from clinicopathological studies on neurodegenerative changes is at odds with these observations. A thorough appraisal of concomitant vascular changes in dementia might resolve this incongruity.

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References

  1. Sonnen, J. A. et al. Different patterns of cerebral injury in dementia with or without diabetes. Arch. Neurol. 66, 315–322 (2009).

    Article  Google Scholar 

  2. Xu, W. L., von Strauss, E., Qiu, C. X., Winblad, B. & Fratiglioni, L. Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study. Diabetologia doi: 10.1007/s00125-009-1323-x.

    Article  CAS  Google Scholar 

  3. Alafuzoff, I., Aho, L., Helisalmi, S., Mannermaa, A. & Soininen, H. β-Amyloid deposition in brains of subjects with diabetes. Neuropathol. Appl. Neurobiol. 35, 60–68 (2009).

    Article  CAS  Google Scholar 

  4. Kalaria, R. N. et al. Towards defining the neuropathological substrates of vascular dementia. J. Neurol. Sci. 226, 75–80 (2004).

    Article  Google Scholar 

  5. van Harten, B., de Leeuw, F. E., Weinstein, H. C., Scheltens, P. & Biessels, G. J. Brain imaging in patients with diabetes: a systematic review. Diabetes Care 29, 2539–2548 (2006).

    Article  Google Scholar 

  6. Beeri, M. S. et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 71, 750–757 (2008).

    Article  CAS  Google Scholar 

  7. Arvanitakis, Z. et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology 67, 1960–1965 (2006).

    Article  CAS  Google Scholar 

  8. Peila, R., Rodriguez, B. L. & Launer, L. J. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes 51, 1256–1262 (2002).

    Article  CAS  Google Scholar 

  9. Wilcock, D. M. & Colton, C. A. Anti-Aβ immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. J. Alzheimers Dis. 15, 555–569 (2008).

    Article  CAS  Google Scholar 

  10. Nelson, P. T. et al. Human cerebral neuropathology of type 2 diabetes mellitus. Biochim. Biophys. Acta 1792, 454–469 (2008).

    Article  Google Scholar 

Download references

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  1. R. N. Kalaria, Institute for Ageing and Health, Wolfson Research Center (Neuropathology), Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 5PL, UK r.n.kalaria@ncl.ac.uk

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  1. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK

    Raj N. Kalaria

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  1. Raj N. Kalaria
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Kalaria, R. Diabetes, microvascular pathology and Alzheimer disease. Nat Rev Neurol 5, 305–306 (2009). https://doi.org/10.1038/nrneurol.2009.72

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