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Dementia

Does vitamin D modulate cognition?

Epidemiological evidence strongly suggests that circulatory levels of 25-hydroxyvitamin D below 50 nmol/l are associated with cognitive impairment and the development of dementia. A number of biochemical mechanisms could explain these effects; however, interventional studies to date have revealed disappointingly little.

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Figure 1: Possible protective mechanisms mediated by vitamin D.

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Correspondence to John E. Morley.

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Morley, J. Does vitamin D modulate cognition?. Nat Rev Neurol 10, 613–614 (2014). https://doi.org/10.1038/nrneurol.2014.193

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