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Osteoarthritis in 2012

Parallel evolution of OA phenotypes and therapies

Nature Reviews Rheumatology volume 9, pages 68–70 (2013)Cite this article

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2012 has witnessed new developments in targeted therapies for osteoarthritis, and in ways to identify those patients who might benefit most from their application. Together, these advances could go some way to addressing the urgent need for disease-modifying treatments for this common disease.

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Figure 1: Putative evolution of OA phenotypes and therapies.

References

  1. Zhang, W. et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 18, 476–499 (2010).

    Article  CAS  Google Scholar 

  2. Wenham, C. Y. & Conaghan, P. G. Imaging the painful osteoarthritic knee joint: what have we learned? Nat. Clin. Pract. Rheumatol. 5, 149–158 (2009).

    PubMed  Google Scholar 

  3. Sellam, J. & Berenbaum, F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat. Rev. Rheumatol. 6, 625–635 (2010).

    Article  CAS  Google Scholar 

  4. Maksymowych, W. P. et al. Targeting tumor necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee. Arthritis Res. Ther. 14, R206 (2012).

    Article  Google Scholar 

  5. Verbruggen, G., Wittoek, R., Vander Cruyssen, B. & Elewaut, D. Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification. Ann. Rheum. Dis. 71, 891–898 (2012).

    Article  CAS  Google Scholar 

  6. Kortekaas, M. C., Kwok, W. Y., Reijnierse, M., Huizinga, T. W. & Kloppenburg, M. In erosive hand osteoarthritis more inflammatory signs on ultrasound are found than in the rest of hand osteoarthritis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2012-201458.

  7. Laslett, L. L. et al. Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial. Ann. Rheum. Dis. 71, 1322–1328 (2012).

    Article  CAS  Google Scholar 

  8. Guermazi, A. et al. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study). BMJ 345, e5339 (2012).

    Article  Google Scholar 

  9. Studer, D., Millan, C., Öztürk, E., Maniura-Weber, K. & Zenobi-Wong, M. Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cells. Eur. Cell. Mater. 24, 118–135 (2012).

    Article  CAS  Google Scholar 

  10. Johnson, K. et al. A stem cell-based approach to cartilage repair. Science 336, 717–721 (2012).

    Article  CAS  Google Scholar 

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Acknowledgements

The author's work is supported in part by funding from Arthritis Research UK.

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  1. Division of Musculoskeletal Disease, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, LS7 4SA, UK

    Philip G. Conaghan

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  1. Philip G. Conaghan
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Conaghan, P. Parallel evolution of OA phenotypes and therapies. Nat Rev Rheumatol 9, 68–70 (2013). https://doi.org/10.1038/nrrheum.2012.225

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