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Epigenetics

DNA methylation signatures in Sjögren syndrome

Nature Reviews Rheumatology volume 12, pages 565–566 (2016)Cite this article

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Changes in DNA methylation patterns are emerging as an important feature in the development and progression of primary Sjögren syndrome. However, questions remain regarding the contribution of epigenetic (and genetic) factors to the recruitment and activation of autoreactive lymphocytes in the glandular tissues primarily affected by the disease.

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Figure 1: DNA methylation influences the development of autoimmune epithelitis in primary Sjögren syndrome.

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Acknowledgements

The authors express their gratitude to W.H. Brooks (University of South Florida, Florida, USA) for editorial assistance. Y.R. and E.B. are supported by European Union/European Federation of Pharmaceutical Industries and Associations Innovative Medicines Initiative Joint Undertaking PRECISESADS (grant 115565).

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Authors and Affiliations

  1. Laboratory of Immunology and Immunotherapy, Brest University Medical School, Hospital Centre Regional University (CHRU) Morvan, 2 Avenue Foch, BP 824, Brest, 29609, France

    Yves Renaudineau

  2. INSERM ERI29/EA2216 Laboratory of Immunotherapies and B cell Pathologies, Labex “Immunotherapy Graft-Oncology”, Réseau épigénétique et réseau canaux ioniques du cancéropole Grand Ouest, University of Brest, Brest, 26609, France

    Yves Renaudineau

  3. Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Avinguda Gran Via 199–203, Barcelona, 08908, Spain

    Esteban Ballestar

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  1. Yves Renaudineau
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  2. Esteban Ballestar
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Correspondence to Yves Renaudineau.

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Renaudineau, Y., Ballestar, E. DNA methylation signatures in Sjögren syndrome. Nat Rev Rheumatol 12, 565–566 (2016). https://doi.org/10.1038/nrrheum.2016.144

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