New data suggest that microRNAs of the miR-371∼373 and miR-302 clusters are promising biomarkers for serum-based detection of malignant germ cell tumours (MGCTs). PCR quantification of these noncoding RNAs can improve the accuracy of MGCT diagnosis, providing greater sensitivity and specificity than traditional markers such as α-fetoprotein and human chorionic gonadotrophin.
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Murray, M., Coleman, N. A new generation of biomarkers for malignant germ cell tumours. Nat Rev Urol 9, 298–300 (2012). https://doi.org/10.1038/nrurol.2012.86
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DOI: https://doi.org/10.1038/nrurol.2012.86
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