The crystal structure of a four-protein complex comprising a SUMO ligase (E3), a SUMOylated protein substrate, and the cognate SUMO-conjugating enzyme sheds new light on catalysis, specificity and SUMO-protein interactions.
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Acknowledgements
We thank C. Lima for providing Figure 1c and M. Hochstrasser for comments on the manuscript. Work in our laboratories is funded by grants from the US National Institutes of Health.
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Matunis, M., Pickart, C. Beginning at the end with SUMO. Nat Struct Mol Biol 12, 565–566 (2005). https://doi.org/10.1038/nsmb0705-565
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DOI: https://doi.org/10.1038/nsmb0705-565
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