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Cells of origin for cancer: an updated view from prostate cancer

Oncogene volume 32, pages 3655–3663 (2013)Cite this article

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Abstract

The cells of origin for cancer are the cells within tissues that serve as the target for transformation. Understanding the nature of these cells will benefit disease prevention, diagnosis and prognosis. During the past decade, much progress has been made in understanding the cellular origin for prostate cancer. This review aims to summarize the previous findings, describe the most recent results and discuss some controversies and unresolved issues in this field.

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Acknowledgements

I apologize to those authors whose work could not be cited because of space limitation, and thank Drs Michael Ittmann and Jeffrey Rosen for critical reading of the manuscript. This work is supported by NIH R00CA125937 (LX), R01DK092202 (LX) and U01CA141497 (MMI).

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  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    L Xin

  2. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA,

    L Xin

  3. Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA,

    L Xin

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Correspondence to L Xin.

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Xin, L. Cells of origin for cancer: an updated view from prostate cancer. Oncogene 32, 3655–3663 (2013). https://doi.org/10.1038/onc.2012.541

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