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Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis

Oncogene volume 35, pages 683–690 (2016)Cite this article

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Abstract

CEP55 was initially identified as a pivotal component of abscission, the final stage of cytokinesis, serving to regulate the physical separation of two daughter cells. Over the past 10 years, several studies have illuminated additional roles for CEP55 including regulating the PI3K/AKT pathway and midbody fate. Concurrently, CEP55 has been studied in the context of cancers including those of the breast, lung, colon and liver. CEP55 overexpression has been found to significantly correlate with tumor stage, aggressiveness, metastasis and poor prognosis across multiple tumor types and therefore has been included as part of several prognostic ‘gene signatures’ for cancer. Here by discussing in depth the functions of CEP55 across different effector pathways, and also its roles as a biomarker and driver of tumorigenesis, we assemble an exhaustive review, thus commemorating a decade of research on CEP55.

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Acknowledgements

DS is supported by a Griffith University International and Postgraduate Research Scholarship. MK is supported by a project grant from Cancer Council Queensland (ID1087363). This work was supported by a program grant from the National Health & Medical Research Council (NHMRC) to KKK (ID 1017028). KKK is a NHMRC Senior Principal Research Fellow (ID 613638).

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Authors and Affiliations

  1. Signal Transduction Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

    J Jeffery, D Sinha, M Kalimutho & K K Khanna

  2. School of Natural Sciences, Griffith University, Brisbane, Queensland, Australia

    D Sinha

  3. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

    S Srihari

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Jeffery, J., Sinha, D., Srihari, S. et al. Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Oncogene 35, 683–690 (2016). https://doi.org/10.1038/onc.2015.128

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